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1. WO2002025287 - DETECTION OF PEPTIDES

Publication Number WO/2002/025287
Publication Date 28.03.2002
International Application No. PCT/GB2001/004182
International Filing Date 19.09.2001
Chapter 2 Demand Filed 11.04.2002
IPC
G01N 33/68 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
CPC
C40B 30/04
CCHEMISTRY; METALLURGY
40COMBINATORIAL TECHNOLOGY
BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
30Methods of screening libraries
04by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
G01N 33/543
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
G01N 33/6803
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
6803General methods of protein analysis not limited to specific proteins or families of proteins
G01N 33/6845
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
6803General methods of protein analysis not limited to specific proteins or families of proteins
6845Methods of identifying protein-protein interactions in protein mixtures
G01N 33/6848
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
6803General methods of protein analysis not limited to specific proteins or families of proteins
6848Methods of protein analysis involving mass spectrometry
Applicants
  • OXFORD GLYCOSCIENCES (UK) LTD. [GB]/[GB] (AllExceptUS)
  • BARRY, Richard [GB]/[GB] (UsOnly)
  • PLATT, Albert, Edward [GB]/[GB] (UsOnly)
  • SCRIVENER, Elaine [GB]/[GB] (UsOnly)
  • SOLOVIEV, Mikhail [GB]/[GB] (UsOnly)
  • TERRETT, Johnathan, Alexander [GB]/[GB] (UsOnly)
Inventors
  • BARRY, Richard
  • PLATT, Albert, Edward
  • SCRIVENER, Elaine
  • SOLOVIEV, Mikhail
  • TERRETT, Johnathan, Alexander
Agents
  • BLAKEY, Alison, Jane
Priority Data
0022978.119.09.2000GB
60/255,36413.12.2000US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DETECTION OF PEPTIDES
(FR) DETECTION DE PEPTIDES
Abstract
(EN)
A method for determining the presence of one or more proteins of interest in a sample, which method comprises the step of: c) submitting the sample to conditions that allow fragmentation of the protein into target peptide fragments; and d) contacting the target peptide fragments with an array of capture agents immobilized on a solid support, the capture agents comprising those that recognize a target protein fragment; whereby the binding of the target peptide fragments with the capture agents is indicative of the presence of the protein(s) in the sample. A device comprising such an array, and its production, are also described.
(FR)
L'invention concerne un procédé de détermination de la présence d'une ou plusieurs protéine(s) présentant un intérêt dans un échantillon. Ce procédé consiste à : c) soumettre ledit échantillon à des conditions permettant la fragmentation de la protéine en divers fragments de peptide cibles; d) mettre en contact lesdits fragments de peptide cibles avec un ensemble d'agents de capture immobilisés sur un support solide, ces agents de capture comportant ceux reconnaissant un fragment de protéine cible; ainsi la liaison des fragments de peptide cibles avec les agents de capture indique la présence de protéine(s) dans l'échantillon. L'invention concerne également un appareil comportant un tel ensemble ainsi que sa production.
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