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1. WO2002024903 - METHOD OF EXAMINING ALLERGIC DISEASE

Publication Number WO/2002/024903
Publication Date 28.03.2002
International Application No. PCT/JP2001/008246
International Filing Date 21.09.2001
Chapter 2 Demand Filed 01.03.2002
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C12Q 1/68 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
CPC
A01K 2217/05
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2217Genetically modified animals
05Animals comprising random inserted nucleic acids (transgenic)
A01K 2217/075
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2217Genetically modified animals
07Animals genetically altered by homologous recombination
075inducing loss of function, i.e. knock out
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61P 17/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
04Antipruritics
A61P 37/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
08Antiallergic agents
Applicants
  • GENOX RESEARCH, INC. [JP]/[JP] (AllExceptUS)
  • JAPAN AS REPRESENTED BY GENERAL DIRECTOR OF AGENCY OF NATIONAL CENTER FOR CHILD HEALTH AND DEVELOPMENT [JP]/[JP] (AllExceptUS)
  • EISAI CO., LTD. [JP]/[JP] (AllExceptUS)
  • SUGITA, Yuji [JP]/[JP] (UsOnly)
  • HASHIDA, Ryoichi [JP]/[JP] (UsOnly)
  • OGAWA, Kaoru [JP]/[JP] (UsOnly)
  • FUJISHIMA, Tomoko [JP]/[JP] (UsOnly)
  • NAGASU, Takeshi [JP]/[JP] (UsOnly)
  • TSUJIMOTO, Gozoh [JP]/[JP] (UsOnly)
  • TAKAHASHI, Eiki [JP]/[JP] (UsOnly)
Inventors
  • SUGITA, Yuji
  • HASHIDA, Ryoichi
  • OGAWA, Kaoru
  • FUJISHIMA, Tomoko
  • NAGASU, Takeshi
  • TSUJIMOTO, Gozoh
  • TAKAHASHI, Eiki
Agents
  • SHIMIZU, Hatsushi
Priority Data
2000-29131825.09.2000JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) METHOD OF EXAMINING ALLERGIC DISEASE
(FR) METHODE D'EXAMEN APPLICABLE EN CAS DE MALADIE ALLERGIQUE
Abstract
(EN)
By using the differential display method, it is attempted to search for a gene showing a difference in expression in eosinophils collected from patients with atopic dermatitis in the increment stage and in the remission stage. As a result, a gene 20-90-05 showing a significant increase in expression in eosinophils of patients in the remission stage is isolated. It is found out that this gene is usable in examining an allergic disease and screening a candidate compound for a remedy therefor.
(FR)
La mise en oeuvre de la méthode de criblage différentiel permet de sélectionner un gène présentant une différence d'expression dans les polynucléaires éosinophiles prélevés chez des patients souffrant de dermatite atopique, au cours du stade d'aggravation et du stade de rémission de la maladie. Cette méthode permet d'isoler un gène '20-90-05' présentant un accroissement d'expression dans les polynucléaires éosinophiles des patients au cours du stade de rémission. Il s'est avéré que ce gène peut être utile à l'examen dans le cas d'une maladie allergique et pour la sélection d'un composé candidat destiné au traitement d'une telle maladie.
Also published as
Latest bibliographic data on file with the International Bureau