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1. WO2002024708 - PRODRUGS OF A 7-ACYLAMINO-3-HETEROARYLTHIO-3-CEPHEM CARBOXYLIC ACID ANTIBIOTIC

Publication Number WO/2002/024708
Publication Date 28.03.2002
International Application No. PCT/US2001/008980
International Filing Date 20.03.2001
Chapter 2 Demand Filed 02.04.2002
IPC
C07D 501/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
501Heterocyclic compounds containing 5-thia-1-azabicyclo octane ring systems, i.e. compounds containing a ring system of the formula: , e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
CPC
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07D 501/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
501Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula: , e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Applicants
  • ESSENTIAL THERAPEUTICS, INC. [US]/[US] (AllExceptUS)
  • HECKER, Scott, J. [US]/[US]
  • CHO, Aesop [US]/[US]
  • GLINKA, Tomasz, W. [PL]/[US]
  • CALKINS, Trevor [US]/[US]
  • LEE, Ving, J. [US]/[US]
Inventors
  • HECKER, Scott, J.
  • CHO, Aesop
  • GLINKA, Tomasz, W.
  • CALKINS, Trevor
  • LEE, Ving, J.
Agents
  • ROSE, Bernard, F.
Priority Data
09/668,72221.09.2000US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PRODRUGS OF A 7-ACYLAMINO-3-HETEROARYLTHIO-3-CEPHEM CARBOXYLIC ACID ANTIBIOTIC
(FR) PROMEDICAMENTS D'UN ANTIBIOTIQUE A BASE D'ACIDE 7-ACYLAMINO-3-HETEROARYLTHIO-3-CEPHEM CARBOXYLIQUE
Abstract
(EN)
The present invention relates to prodrugs of the antibiotic compound (7R)-7-[(Z)-2-(2-amino-5-chlorothiazol-4-yl)-2-(hydroxylimino)acetamido]acetamidol]-3-{3-(2-aminoethylthiomethyl]-pyrid-4-ylthio}-3-cephem-4-carbocyllic acid, where the prodrugs are substantially more water soluble at or near neutral pH than the parent compound.
(FR)
La présente invention concerne des promédicaments du composé antibiotique acide (7R)-7-[(Z)-2-(2-amino-5-chlorothiazol-4-yl)-2-(hydroxylimino)acétamido]acétamidol]-3-{3-(2-aminoéthylthiométhyl]-pyrid-4-ylthio}-3-céphème-4- carboxylique, les promédicaments étant sensiblement plus solubles dans une eau à pH neutre ou proche d'un pH neutre que le composé d'origine.
Latest bibliographic data on file with the International Bureau