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1. WO2002022852 - METHOD FOR MEASURING ANTITHROMBIN ACTIVITY

Publication Number WO/2002/022852
Publication Date 21.03.2002
International Application No. PCT/CA2001/001297
International Filing Date 12.09.2001
Chapter 2 Demand Filed 12.04.2002
IPC
G01N 33/86 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
86involving blood coagulating time
CPC
G01N 33/86
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
86involving blood coagulating time ; or factors, or their receptors
Y10S 435/975
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
435Chemistry: molecular biology and microbiology
975Kit
Applicants
  • AFFINITY BIOLOGICALS INCORPORATED [CA]/[CA]
  • R2 DIAGNOSTICS, INC. [US]/[US]
Inventors
  • HOOGENDOORN, Hugh, W.
  • DUNCAN, Alexander
  • MORRIS, Michael, J.
Agents
  • SMART & BIGGAR
  • FAGGETTER, Ronald, D.
Priority Data
09/661,14213.09.2000US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR MEASURING ANTITHROMBIN ACTIVITY
(FR) PROCEDE DE MESURE DE L'ACTIVITE DE L'ANTITHROMBINE
Abstract
(EN)
The invention provides a one-stage method of measuring antithrombin (AT) activity in a sample. In the method, a diluted sample is mixed with AT-deficient plasma containing intrinsic coagulation enzymes, an AT augmenting compound such as heparin, a phospholipid and an activator of the contact phase of the intrinsic coagulation pathway. Following addition of calcium ions, coagulation time is measured and compared to a reference standard to determine the level of AT activity in the sample.
(FR)
L'invention concerne un procédé à étape unique de mesure de l'activité de l'antithrombine (AT) dans un échantillon. On mélange un échantillon dilué avec du plasma déficient en antithrombine qui renferme des enzymes de coagulation intrinsèques, un composé à capacité d'augmentation de l'antithrombine du type héparine, un phospholipide et un activateur de la phase de contact du trajet de coagulation intrinsèque. Après l'adjonction d'ions calcium, on mesure le temps de coagulation et on le compare à une norme de référence pour déterminer le niveau d'activité de l'antithrombine dans l'échantillon.
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