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1. WO2002022808 - CRIPTO MUTANT AND USES THEREOF

Publication Number WO/2002/022808
Publication Date 21.03.2002
International Application No. PCT/US2001/029066
International Filing Date 18.09.2001
Chapter 2 Demand Filed 17.04.2002
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/475 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
475Growth factors; Growth regulators
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
C07K 14/475
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
475Growth factors; Growth regulators
C07K 2319/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
Applicants
  • BIOGEN, INC. [US]/[US] (AllExceptUS)
  • WILLIAMS, Kevin, P. [GB]/[US] (UsOnly)
  • FOLEY, Susan [US]/[US] (UsOnly)
  • SCHIFFER, Susan [US]/[US] (UsOnly)
  • DOMON, Bruno [CH]/[US] (UsOnly)
  • SANICOLA-NADEL, Michele [US]/[US] (UsOnly)
Inventors
  • WILLIAMS, Kevin, P.
  • FOLEY, Susan
  • SCHIFFER, Susan
  • DOMON, Bruno
  • SANICOLA-NADEL, Michele
Agents
  • COX, Niki, D.
Priority Data
60/233,14818.09.2000US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CRIPTO MUTANT AND USES THEREOF
(FR) MUTANT CRIPTO ET UTILISATIONS DE CE DERNIER
Abstract
(EN)
The present invention is based on the discovery that CRIPTO mutants each comprising at least one amino acid substitution from a CRIPTO polypeptide demonstrate tumor blocking activity.
(FR)
La présente invention se rapporte à la découverte que les mutants CRIPTO qui comprennent chacun au moins une substitution d'acide aminé par rapport à un polypeptide CRIPTO présentent une activité de blocage des tumeurs. .
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