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1. WO2002022629 - ANTI-STILBENE ANTIBODIES

Publication Number WO/2002/022629
Publication Date 21.03.2002
International Application No. PCT/US2001/042160
International Filing Date 13.09.2001
Chapter 2 Demand Filed 10.04.2002
IPC
C12N 9/00 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
G01N 33/53 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
CPC
C12N 9/0002
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
0002Antibodies with enzymatic activity, e.g. abzymes
G01N 33/5308
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
5308for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
Applicants
  • THE SCRIPPS RESEARCH INSTITUTE [US]/[US] (AllExceptUS)
  • WIRSCHING, Peter [US]/[US] (UsOnly)
  • JANDA, Kim, D. [US]/[US] (UsOnly)
  • LERNER, Richard, A. [US]/[US] (UsOnly)
Inventors
  • WIRSCHING, Peter
  • JANDA, Kim, D.
  • LERNER, Richard, A.
Agents
  • NORTHRUP, Thomas, E.
Priority Data
09/661,24313.09.2000US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ANTI-STILBENE ANTIBODIES
(FR) ANTICORPS ANTI-STILBENE
Abstract
(EN)
The present invention provides an anti-stilbene antibody. Preferably, the antibody is a monoclonal antibody. Exemplary and preferred such antibodies are designated herein as 19G2, 20F2, 21C6, 22B9, 25F8, 25E2, 23E4, 23G3, 23D3, 23C2, 25C10, 24B6, 21E2, 16H10 and 9E11. The present invention further provides hybridomas that produce and secrete anti-stilbene antibodies. An antibody of the present invention has particular utility in processes for identifying and/or locating target moieties appended to or incorporating antigenic stilbene. In one embodiment, therefore, the present invention further provides a method of detecting antigenic stilbene. The method includes the steps of exposing antigenic stilbene to an anti-stilbene antibody and detecting an anti-stilbene antibody-stilbene immunoconjugate. Such immunoconjugates can be detected using fluoroscopic procedures.
(FR)
L'invention porte sur un anticorps anti-stilbène de préférence du type monoclonal. A titre d'exemple, les anticorps préférés sont les 19G2, 20F2, 21C6, 22B9, 25F8, 25E2, 23E4, 23G3, 23D3, 23C2, 25C10, 24B6, 21E2, 16H10 et 9E11, et sur des hybridomes produisant et sécrétant lesdits anticorps. Un anticorps de l'invention présente une utilité particulière dans les processus d'identification et/ou de localisation de fragments cibles attenant à ou incorporant des stilbènes antigènes. C'est pourquoi l'invention constitue une méthode de détection des stilbènes antigènes. Le procédé associé comporte une étape d'exposition d'un stilbène antigène à un anticorps anti-stilbène, et une étape de détection d'un immunocongugué anticorps anti-stilbène/stilbène, cette détection pouvant s'opérer par fluoroscopie.
Also published as
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