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1. (WO2002022574) TRICYCLIC HETEROCYCLIC COMPOUND, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2002/022574 International Application No.: PCT/JP2001/007815
Publication Date: 21.03.2002 International Filing Date: 10.09.2001
Chapter 2 Demand Filed: 05.10.2001
IPC:
C07D 471/14 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
12
in which the condensed system contains three hetero rings
14
Ortho-condensed systems
Applicants:
TAKEDA CHEMICAL INDUSTRIES, LTD. [JP/JP]; 1-1, Doshomachi 4-chome, Chuo-ku Osaka-shi, Osaka 540-8645, JP (AllExceptUS)
IKEURA, Yoshinori [JP/JP]; JP (UsOnly)
HASHIMOTO, Tadatoshi [JP/JP]; JP (UsOnly)
TARUI, Naoki [JP/JP]; JP (UsOnly)
KAMO, Izumi [JP/JP]; JP (UsOnly)
SHIRAI, Junya [JP/JP]; JP (UsOnly)
Inventors:
IKEURA, Yoshinori; JP
HASHIMOTO, Tadatoshi; JP
TARUI, Naoki; JP
KAMO, Izumi; JP
SHIRAI, Junya; JP
Agent:
TAKASHIMA, Hajime; Fujimura Yamato Seimei Bldg. 2-14, Fushimimachi 4-chome, Chuo-ku Osaka-shi, Osaka 541-0044, JP
Priority Data:
2000-28015411.09.2000JP
Title (EN) TRICYCLIC HETEROCYCLIC COMPOUND, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF
(FR) COMPOSE TRICYCLIQUE HETEROCYCLIQUE, SON PROCEDE DE FABRICATION ET SON UTILISATION
Abstract:
(EN) A compound represented by the formula, a salt thereof, or a prodrug thereof: (I) wherein R1 represents hydrogen, optionally substituted alkyl, aryl, acyl, alkoxycarbonyl, carbamoyl, mono- or dialkylcarbamoyl, or alkylsulfonyl; R2 represents hydrogen, halogeno, or optionally halogenated alkyl; R3 represents hydrogen or alkyl; R represents hydrogen, halogeno, optionally halogenated alkyl, or optionally halogenated alkoxy; m is an integer of 0 to 3; n is 1 or 2; and p is an integer of 0 to 3, provided that when R1 and R2 are methyl, R3 is hydrogen, the group represented by formula (A) is the group represented by formula (B), and m is 1, then n is 1. The compound has an antagonistic effect on tachykinin receptors, especially on a substance P receptor, and is useful as a medicine such as a urination anomaly ameliorant.
(FR) Cette invention concerne un composé représenté par la formule (I) ainsi qu'un sel de ce composé. Dans cette formule, R1 représente hydrogène, alkyle éventuellement substitué, aryle, acyle, alkoxycarbonyle, carbamoyle, mono- ou dialkylcarbamoyle, ou alkylsulfonyle ; R2 représente hydrogène, halogéno ou alkyle éventuellement halogéné ; R3 représente hydrogène ou alkyle ; R représente hydrogène, halogéno, alkyle éventuellement halogéné ou alkoxy éventuellement halogéné ; m est un entier entre 0 et 3 ; n vaut 1 ou 2 ; et p est un entier entre 0 et 3, à condition que lorsque R1 et R2 sont méthyle, R3 est hydrogène, le groupe représenté par la formule (A) est le groupe représenté par la formule (B), et m vaut 1, alors n est égal à 1. Ce composé a un effet antagoniste sur les récepteurs de la tachykinine, en particulier sur un récepteur de la substance P, et convient bien comme médicament permettant d'atténuer les troubles urinaires.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
AU2001286188