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1. WO2002022568 - ß-THIO-AMINO ACIDS

Publication Number WO/2002/022568
Publication Date 21.03.2002
International Application No. PCT/EP2001/010488
International Filing Date 11.09.2001
Chapter 2 Demand Filed 12.04.2002
IPC
A61K 31/198 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
197the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid (GABA), beta-alanine, epsilon-aminocaproic acid, pantothenic acid
198Alpha-amino acids, e.g. alanine, edetic acid (EDTA)
C07C 323/58 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
323Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
50containing thio groups and carboxyl groups bound to the same carbon skeleton
51having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
57the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
58with amino groups bound to the carbon skeleton
C07C 323/61 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
323Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
50containing thio groups and carboxyl groups bound to the same carbon skeleton
61having the sulfur atom of at least one of the thio groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
C07D 333/24 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
333Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
02not condensed with other rings
04not substituted on the ring sulfur atom
06with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
24Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
CPC
A61K 31/198
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
197the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
198Alpha-aminoacids, e.g. alanine, edetic acids [EDTA],
C07C 2601/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2601Systems containing only non-condensed rings
02with a three-membered ring
C07C 2601/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2601Systems containing only non-condensed rings
04with a four-membered ring
C07C 2601/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2601Systems containing only non-condensed rings
12with a six-membered ring
14The ring being saturated
C07C 2601/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2601Systems containing only non-condensed rings
18with a ring being at least seven-membered
C07C 323/58
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
323Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
50containing thio groups and carboxyl groups bound to the same carbon skeleton
51having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
57the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
58with amino groups bound to the carbon skeleton
Applicants
  • GRÜNENTHAL GMBH [DE]/[DE] (AllExceptUS)
  • CHIZH, Boris [RU]/[GB] (UsOnly)
  • GERLACH, Matthias [DE]/[DE] (UsOnly)
  • HAURAND, Michael [DE]/[DE] (UsOnly)
  • PÜTZ, Claudia [DE]/[DE] (UsOnly)
  • GAUBE, Gero [DE]/[DE] (UsOnly)
  • ENDERS, D. [DE]/[DE] (UsOnly)
Inventors
  • CHIZH, Boris
  • GERLACH, Matthias
  • HAURAND, Michael
  • PÜTZ, Claudia
  • GAUBE, Gero
  • ENDERS, D.
Priority Data
100 45 831.914.09.2000DE
100 49 484.629.09.2000DE
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(DE) $g(b)-THIO-AMINOSÄUREN
(EN) ß-THIO-AMINO ACIDS
(FR) ACIDES $G(B)-THIO-AMINES
Abstract
(DE)
Die vorliegende Erfindung betrifft $g(b)-Thio-$g(a)-Aminosäuren der allgemeinen Formel (I), worin R1, R2, R3 die in der Beschreibung angegebenen Bedeutungen haben, Verfahren zu deren Herstellung, Arzneimittel enthaltend diese Verbindungen und die Verwendung von Thioaminosäuren zur Herstellung von Arzneimitteln.
(EN)
The invention relates to thio-$g(a)-amino acids of general formula (I), wherein R1, R2 and R3 have the meanings given in the description, to methods for producing them, to medicaments containing these compounds and to the use of thioamino acids for producing medicaments.
(FR)
L'invention concerne des acides ß-thio-$g(a)-aminés de formule générale (I), dans laquelle R1, R2 et R3 ont la signification indiquée dans la description, leur procédé de production, un médicament contenant ces composés et l'utilisation d'acides thio-aminés pour la production de médicaments.
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