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1. WO2002020847 - GENE AND SEQUENCE VARIATION ASSOCIATED WITH LIPID DISORDER

Publication Number WO/2002/020847
Publication Date 14.03.2002
International Application No. PCT/US2001/028181
International Filing Date 07.09.2001
Chapter 2 Demand Filed 28.03.2002
IPC
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C12Q 1/68 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
CPC
C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
C12Q 2600/136
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
136Screening for pharmacological compounds
Applicants
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US]/[US] (AllExceptUS)
  • BODNAR, Jackie, S. [US]/[US] (UsOnly)
  • CASTELLANI, Lawrence, W. [US]/[US] (UsOnly)
  • CHATTERJEE, Aurobindo [IN]/[US] (UsOnly)
  • DE JONG, Pieter [US]/[US] (UsOnly)
  • LUSIS, Aldons, J. [US]/[US] (UsOnly)
  • OHMEN, Jeff [US]/[US] (UsOnly)
  • ROSS, David [US]/[US] (UsOnly)
  • TAFURI, Sherrie [US]/[US] (UsOnly)
  • WU, Chenyan [CN]/[US] (UsOnly)
Inventors
  • BODNAR, Jackie, S.
  • CASTELLANI, Lawrence, W.
  • CHATTERJEE, Aurobindo
  • DE JONG, Pieter
  • LUSIS, Aldons, J.
  • OHMEN, Jeff
  • ROSS, David
  • TAFURI, Sherrie
  • WU, Chenyan
Agents
  • HALLUIN, Albert, P.
Priority Data
60/231,32208.09.2000US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) GENE AND SEQUENCE VARIATION ASSOCIATED WITH LIPID DISORDER
(FR) GENE ET VARIATION DE SEQUENCE ASSOCIES A DES TROUBLES LIPIDIQUES
Abstract
(EN)
The present invention relates to the discovery of gene and its sequence variation associated with lipid disorder and cancer. The present invention also relates to the study of metabolic pathways and cellular mechanisms to identify other genes, receptors, and relationships that contribute to lipid disorder and cancer. The present invention also relates to germline or somatic sequence variation and its use in the diagnosis and prognosis of predisposition to lipid disorder and cancer. The present invention also provides primers or probes specific for the detection and analysis of such sequence variation. The present invention also relates to methods to screen drugs for inhibition or restoration of gene function as an anti-lipid disorder or anti-cancer therapy. Finally, the present invention relates to other anti-lipid disorder or anti-cancer therapies, such as gene therapy, protein replacement therapy, etc.
(FR)
L'invention concerne un gène et sa variation de séquence associée à des troubles lipidiques et au cancer. Elle concerne aussi l'étude des voies métaboliques et des mécanismes cellulaires permettant d'identifier d'autres gènes, des récepteurs, et des relations qui contribuent aux troubles lipidiques et au cancer. Elle concerne aussi une variation de séquence somatique ou germinale et son utilisation dans le diagnostic ou le pronostic d'une prédisposition aux troubles lipidiques et au cancer, ainsi que des amorces ou des sondes spécifiques pour la détection et l'analyse d'une telle variation de séquence. Elle concerne encore des procédés de criblage de médicaments destinés à inhiber ou à restaurer la fonction génique en tant que thérapie contre des troubles lipidiques ou anticancéreuse. Elle concerne enfin d'autres thérapies contre des troubles lipidiques ou anticancéreuses, telles que la thérapie génique, la thérapie de remplacement de protéine, et d'autres thérapies du même genre.
Also published as
Latest bibliographic data on file with the International Bureau