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1. WO2002020782 - A SENSE ANDANTISNSE OLIGONUCLEOTIDES OF V-ERBB GENE AND USES THEREOF

Publication Number WO/2002/020782
Publication Date 14.03.2002
International Application No. PCT/CN2001/000888
International Filing Date 01.06.2001
Chapter 2 Demand Filed 20.12.2001
IPC
A61K 48/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C07K 14/71 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
71for growth factors; for growth regulators
CPC
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 14/71
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
71for growth factors; for growth regulators
Applicants
  • FENG, Baozhang [CN]/[CN]
Inventors
  • FENG, Baozhang
Agents
  • NTD PATENT & TRADEMARK AGENCY LTD., BEIJING OFFICE
Priority Data
00 1 09023.201.06.2000CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) A SENSE ANDANTISNSE OLIGONUCLEOTIDES OF V-ERBB GENE AND USES THEREOF
(FR) OLIGONUCLEOTIDES SENS ET ANTISENS DE V-ERBB ET SES APPLICATIONS
Abstract
(EN)
The invention relates to a pair of PCR primers specific for V-erbB gene, the sequence of V-erbB gene specified by the pair of primers, the polypeptide transcribed by the sequence, vaccine comprising the V-erbB sequence or polypeptide thereof, and a sense and antisense oligonucleotides of V-erbB gene designed based on the sequence of V-erbB gene. The invention also relates to a kit comprising above primers or a sense oligonucleotides of V-erbB gene, pharmaceutical composition comprising antisense oligonucleotides of V-erbB gene, and uses thereof in the diagnosis and treatment of myelosis abnormality syndrome, leukosis, other multiple tumor and prophasing.
(FR)
L'invention concerne une paire d'amorces PCR ayant un effet positif sur les oligonucléotides de V-erbB, une séquence de V-erbB limitée par ladite paire d'amorces, un ARNm de transcription de ladite séquence, un vaccin comprenant ladite séquence V-erbB ou un polypeptide et un oligonucléotide sens et antisens s'adaptant à la séquence de V-erbB. L'invention concerne également un agent de diagnostic renfermant lesdites amorces ou lesdits oligonucléotides sens et antisens, un composé pharmaceutique renfermant ledit oligonucléotide antisens, ainsi que les applications des substances précitées en vue du diagnostic et du traitement du syndrome myélodysplasique, de la leucémie, d'autres tumeurs et des étapes précédant ces pathologies.
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