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1. WO2002020771 - NUCLEOTIDE SEQUENCES CODING FOR THE HISC2 GENE

Publication Number WO/2002/020771
Publication Date 14.03.2002
International Application No. PCT/EP2001/009037
International Filing Date 04.08.2001
Chapter 2 Demand Filed 22.03.2002
IPC
C12N 9/10 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10Transferases (2.)
C12P 13/08 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
13Preparation of nitrogen-containing organic compounds
04Alpha- or beta-amino acids
08Lysine; Diaminopimelic acid; Threonine; Valine
CPC
C12N 9/1096
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
10Transferases (2.)
1096transferring nitrogenous groups (2.6)
C12P 13/08
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
13Preparation of nitrogen-containing organic compounds
04Alpha- or beta- amino acids
08Lysine; Diaminopimelic acid; Threonine; Valine
C12Y 206/01009
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
YENZYMES
206Transferases transferring nitrogenous groups (2.6)
01Transaminases (2.6.1)
01009Histidinol-phosphate transaminase (2.6.1.9)
Applicants
  • DEGUSSA AG [DE]/[DE]
Inventors
  • FARWICK, Mike
  • HUTHMACHER, Klaus
  • BATHE, Brigitte
  • PFEFFERLE, Walter
Priority Data
100 44 709.009.09.2000DE
101 08 838.823.02.2001DE
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NUCLEOTIDE SEQUENCES CODING FOR THE HISC2 GENE
(FR) SEQUENCES NUCLEOTIDIQUES CODANT POUR LE GENE HISC2
Abstract
(EN)
The invention relates to an isolated polynucleotide (1) and a process for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the hisC2 gene is present in the attenuated form, and the use of polynucleotides containing the sequences according to the invention as hybridization probes from coryneform bacteria (1) coding for the KisC2 gene.
(FR)
Cette invention se rapporte à un polynucléotide isolé contenant une séquence polynucléotidique choisie dans le groupe comprenant: a) un polynucléotide qui est identique à au moins 70 % à un polynucléotide codant pour un polypeptide qui contient la séquence d'acides aminés du numéro d'identification de séquence 2; b) un polynucléotide qui code pour un polypeptide contenant une séquence d'acides aminés qui est identique à au moins 70 % à la séquence d'acides aminés du numéro d'identification de séquence 2; c) un polynucléotide qui est complémentaire des polynucléotides de a) ou b), et d) un polynucléotide contenant au moins 15 nucléotides successifs de la séquence polynucléotidique de a), b) ou c). Cette invention concerne en outre un procédé servant à la préparation par fermentation d'acides L-amino, en utilisant la bactérie corynéforme, dans laquelle au moins le gène hisC2 est présent dans sa forme atténuée, et à l'utilisation de polynucléotides contenant ces séquences comme sondes d'hybridation.
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