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1. WO2002020568 - MUTANT PEPTIDES DERIVED FROM BAD AND THEIR USE TO IDENTIFY SUBSTANCES WHICH BIND TO A MEMBER OF THE BCL-2 FAMILY OF PROTEINS

Publication Number WO/2002/020568
Publication Date 14.03.2002
International Application No. PCT/US2001/027410
International Filing Date 04.09.2001
IPC
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
CPC
C07K 14/4702
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
4701not used
4702Regulators; Modulating activity
Applicants
  • ABBOTT LABORATORIES [US]/[US]
Inventors
  • FESIK, Stephen, W.
  • MEADOWS, Robert, P.
  • JOSEPH, Mary, K.
  • OLEJNICZAK, Edward, T.
  • PETROS, Andrew, M.
  • NETTESHEIM, David, G.
  • SWIFT, Kerry, M.
  • MATAYOSHI, Edmund
  • ZHANG, Haichao
Agents
  • CASUTO, Dianne
Priority Data
09/656,39906.09.2000US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MUTANT PEPTIDES DERIVED FROM BAD AND THEIR USE TO IDENTIFY SUBSTANCES WHICH BIND TO A MEMBER OF THE BCL-2 FAMILY OF PROTEINS
(FR) PEPTIDES MUTANTS DERIVES DE BAD ET LEUR UTILISATION POUR IDENTIFIER DES SUBSTANCES SE LIANT A UN ELEMENT DE LA FAMILLE DE PROTEINES BCL-2
Abstract
(EN)
The present invention relates to peptides derived from the wild-type human Bad peptide which bind to a member of the Bcl-2 family of proteins. The peptides of the present invention can be used in an assay to identify candidate substances which induce or promote apoptosis in cells.
(FR)
L'invention concerne des peptides dérivés du peptide Bad humain de type sauvage, ce dernier ce liant à un élément de la famille de protéines Bcl-2. Les peptides de cette invention peuvent être utilisés dans des analyses pour identifier des substances candidates induisant ou promouvant l'apoptose dans les cellules.
Latest bibliographic data on file with the International Bureau