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1. WO2002020475 - INHIBITORS OF SERINE PROTEASE ACTIVITY OF MATRIPTASE OR MTSP1

Publication Number WO/2002/020475
Publication Date 14.03.2002
International Application No. PCT/US2001/028137
International Filing Date 07.09.2001
Chapter 2 Demand Filed 28.02.2002
IPC
C12N 9/64 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
48acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
50Proteinases
64derived from animal tissue, e.g. rennin
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
04specific for metastasis
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C12N 9/6424
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
14Hydrolases (3)
48acting on peptide bonds (3.4)
50Proteinases ; , e.g. Endopeptidases (3.4.21-3.4.25)
64derived from animal tissue
6421from mammals
6424Serine endopeptidases (3.4.21)
Applicants
  • CORVAS INTERNATIONAL, INC. [US]/[US] (AllExceptUS)
  • DUNCAN, David, F. [US]/[US] (UsOnly)
  • MADISON, Edwin, L. [US]/[US] (UsOnly)
  • SEMPLE, Joseph, Edward [US]/[US] (UsOnly)
  • COOMBS, Gary, Samuel [US]/[US] (UsOnly)
  • REINER, John, Eugene [US]/[US] (UsOnly)
  • ONG, Edgar, O. [CA]/[US] (UsOnly)
  • ARALDI, Gian, Luca [IT]/[US] (UsOnly)
Inventors
  • DUNCAN, David, F.
  • MADISON, Edwin, L.
  • SEMPLE, Joseph, Edward
  • COOMBS, Gary, Samuel
  • REINER, John, Eugene
  • ONG, Edgar, O.
  • ARALDI, Gian, Luca
Agents
  • BIGGS, Suzanne
  • VOSSIUS & PARTNER
Priority Data
09/657,98608.09.2000US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) INHIBITORS OF SERINE PROTEASE ACTIVITY OF MATRIPTASE OR MTSP1
(FR) INHIBITEURS DE L'ACTIVITE DE LA SERINE PROTEASE DE MATRIPTASE, OU MTSP1
Abstract
(EN)
The present invention provides compounds which inhibit serine protease activity of matriptase or MTSP1. Also provided are pharmaceutical compositions comprising those compounds and methods of using the compounds and pharmceutical compositions to treat conditions ameliorated by inhibition of matriptase or MTSP1.
(FR)
L'invention concerne des composés qui inhibent l'activité de la sérine protéase de matriptase, ou MTSP1. Par ailleurs, l'invention concerne des compositions pharmaceutiques renfermant ces composés ainsi que des méthodes d'utilisation de ces composés et de ces compositions pharmaceutiques pour traiter des états pathologiques qui s'améliorent avec l'inhibition de matriptase, ou MTSP1.
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