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1. WO2002020038 - METHOD FOR DOWN-REGULATING IGE

Publication Number WO/2002/020038
Publication Date 14.03.2002
International Application No. PCT/DK2001/000579
International Filing Date 06.09.2001
Chapter 2 Demand Filed 01.03.2002
IPC
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61P 29/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A61P 37/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
A61P 37/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
08Antiallergic agents
C07K 16/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
C07K 19/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
CPC
A61K 2039/6037
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
60characteristics by the carrier linked to the antigen
6031Proteins
6037Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
A61K 39/0008
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
0005Vertebrate antigens
0008Antigens related to auto-immune diseases; Preparations to induce self-tolerance
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 37/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
A61P 37/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
A61P 37/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
08Antiallergic agents
Applicants
  • PHARMEXA A/S [DK]/[DK] (AllExceptUS)
  • KLYSNER, Steen [DK]/[DK] (UsOnly)
  • VON HOEGEN, Paul [DE]/[DK] (UsOnly)
  • VOLDBORG, Bjørn [DK]/[DK] (UsOnly)
  • GAUTAM, Anand [GB]/[DK] (UsOnly)
Inventors
  • KLYSNER, Steen
  • VON HOEGEN, Paul
  • VOLDBORG, Bjørn
  • GAUTAM, Anand
Agents
  • KOEFOED, Peter
Priority Data
60/232,83115.09.2000US
PA 2000 0132606.09.2000DK
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR DOWN-REGULATING IGE
(FR) PROCEDE DE REGULATION NEGATIVE D'IGE
Abstract
(EN)
The present invention discloses methods for immunizing against autologous (self) Immunoglobulin E (IgE). In particular, the invention discloses methods for inducing cytotoxic T-lymphocytes that will specifically down-regulate B-cells producing autologous IgE, notably by means of nucleic acid vaccination or live vaccination. Also disclosed are methods for inducing antibodies reactive with autologous IgE as well as methods for inducing a combined antibody and CTK response specific for IgE. The invention also discloses specific immunogenic protein constructs, nucleic acids encoding these as well as various formulations and tools for preparing the vaccines, including vectors and transformed host cells.
(FR)
L'invention concerne des procédés d'immunisation contre les immunoglobines E (IgE) autologues. En particulier, l'invention concerne des procédés visant à induire des lymphocytes T cytotoxiques qui régulent négativement les lymphocytes B produisant les IgE autologues, notamment au moyen d'une vaccination à acide nucléique ou d'une vaccination à viru vivant. L'invention concerne aussi des procédés visant à induire des anticorps réagissant avec les IgE autologues, et des procédés visant à induire un anticorps combiné et une réponse de CTK spécifique d'IgE. L'invention concerne en outre des protéines chimères immunogènes spécifiques, des acides nucléiques codant pour celles-ci ainsi que diverses formulations et outils utiles pour la préparation de vaccins, ainsi que des vecteurs et des cellules hôtes transformées.
Also published as
IN122/MUMNP/2003
IL154219
ZA200302628
Latest bibliographic data on file with the International Bureau