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1. WO2002018437 - CYCLIC PEPTIDES HAVING MELANOCORTIN-4 RECEPTOR AGONIST ACTIVITY

Publication Number WO/2002/018437
Publication Date 07.03.2002
International Application No. PCT/EP2001/009630
International Filing Date 21.08.2001
Chapter 2 Demand Filed 22.02.2002
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/68 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
665derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
68Melanocyte-stimulating hormone (MSH)
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 3/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
A61P 3/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
04Anorexiants; Antiobesity agents
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07K 14/68
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
665derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
68Melanocyte-stimulating hormone [MSH]
C07K 7/56
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
50Cyclic peptides containing at least one abnormal peptide link
54with at least one abnormal peptide link in the ring
56the cyclisation not occurring through 2,4-diamino-butanoic acid
Applicants
  • F. HOFFMANN-LA ROCHE AG [CH]/[CH]
Inventors
  • CHEN, Li
  • CHEUNG, Adrian, Wai-Hing
  • CHU, Xin-Jie
  • DANHO, Waleed
  • SWISTOK, Joseph
  • WANG, Yao
  • YAGALOFF, Keith, Alan
Agents
  • WITTE, Hubert
Priority Data
60/229,18430.08.2000US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CYCLIC PEPTIDES HAVING MELANOCORTIN-4 RECEPTOR AGONIST ACTIVITY
(FR) PEPTIDES CYCLIQUES SÉLECTIFS
Abstract
(EN)
The presente invention refers to peptides cyclized via disulfide or lactam bridges having melanocortin-4 receptor (MC4-R) agonist activity useful for treatment of obesity.
(FR)
La présente invention concerne des peptides rendu cycliques par des passerelles disulfure ou lactame. Ces peptides, qui font preuve d'une activité agonsite du récepteur de la mélanocortine 4 (MC4-R), conviennent particulièrement pour le traitement de l'obésité.
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