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1. WO2002018425 - '47324', A NOVEL G-PROTEIN AND USES THEREFOR

Publication Number WO/2002/018425
Publication Date 07.03.2002
International Application No. PCT/US2001/027197
International Filing Date 31.08.2001
Chapter 2 Demand Filed 12.02.2002
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/4722
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
4701not used
4722G-proteins
Applicants
  • MILLENNIUM PHARMACEUTICALS, INC. [US]/[US] (AllExceptUS)
  • MEYERS, Rachel, E. [US]/[US] (UsOnly)
Inventors
  • MEYERS, Rachel, E.
Agents
  • FAVORITO, Carolyn, A.
Priority Data
60/229,29301.09.2000US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) '47324', A NOVEL G-PROTEIN AND USES THEREFOR
(FR) 47324, NOUVELLE PROTEINE G HUMAINE ET SES UTILISATIONS
Abstract
(EN)
The invention provides isolated nucleic acids molecules, designated 47324 nucleic acid molecules, which encode novel G-protein family members, preferably Ras family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 47324 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 47324 gene has been introduced or disrupted. The invention still further provides isolated 47324 proteins, fusion proteins, antigenic peptides and anti-47324 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
(FR)
L'invention concerne des molécules d'acides nucléiques isolées, appelées molécules d'acides nucléiques 47324, qui codent de nouveaux membres de la famille des protéines G, de préférence des membres de la famille Ras. L'invention concerne également des molécules d'acides nucléiques antisens, des vecteurs d'expression recombinants contenant des molécules d'acides nucléiques 47324, des cellules hôtes dans lesquelles lesdits vecteurs d'expression ont été introduits et des animaux transgéniques non humains dans lesquels un gène 47324 a été introduit ou interrompu. L'invention concerne en outre des protéines 47324 isolées, des protéines de fusion, des peptides antigéniques et des anticorps anti-47324. Sont également décrites des méthodes diagnostiques faisant appel à des compositions obtenues selon l'invention.
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