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1. WO2002018395 - PHOSPHATE DERIVATIVES AS IMMUNOREGULATORY AGENTS

Publication Number WO/2002/018395
Publication Date 07.03.2002
International Application No. PCT/US2001/026789
International Filing Date 28.08.2001
Chapter 2 Demand Filed 19.03.2002
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
06
without P-C bonds
08
Esters of oxyacids of phosphorus
09
Esters of phosphoric acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
28
with one or more P-C bonds
38
Phosphonic acids (R-P(:O)(OH)2); Thiophosphonic acids
C07F 9/09 (2006.01)
C07F 9/38 (2006.01)
CPC
C07F 9/094
C07F 9/3882
Applicants
  • MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue Rahway, NJ 07065-0907, US (AllExceptUS)
  • MANDALA, Suzanne [US/US]; US (UsOnly)
  • BERGSTROM, James [US/US]; US (UsOnly)
  • HAJDU, Richard [US/US]; US (UsOnly)
  • ROSEN, Hugh [US/US]; US (UsOnly)
  • PARSONS, William, H. [US/US]; US (UsOnly)
  • CARD, Deborah, J. [US/US]; US (UsOnly)
  • MACCOSS, Malcolm [GB/US]; US (UsOnly)
  • RUPPRECHT, Kathleen [US/US]; US (UsOnly)
Inventors
  • MANDALA, Suzanne; US
  • BERGSTROM, James; US
  • HAJDU, Richard; US
  • ROSEN, Hugh; US
  • PARSONS, William, H.; US
  • CARD, Deborah, J.; US
  • MACCOSS, Malcolm; US
  • RUPPRECHT, Kathleen; US
Common Representative
  • MERCK & CO., INC.; 126 East Lincoln Avenue Rahway, NJ 07065-0907, US
Priority Data
60/229,43831.08.2000US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PHOSPHATE DERIVATIVES AS IMMUNOREGULATORY AGENTS
(FR) DERIVES DE PHOSPHATES UTILISES EN TANT QU'AGENTS IMMUNO-REGULATEURS
Abstract
(EN)
Immunoregulatory compounds are disclosed of the formula: and as well as the pharmaceutically acceptable salts and hydrates thereof, are disclosed. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, organ and tissue transplant rejection. Pharmaceutical compositions and methods of use are included.
(FR)
L'invention concerne des composés immuno-régulateurs de formule 1 et A, ainsi que des sels et des hydrates pharmaceutiquement acceptables de ces derniers. Les composés sont utiles dans le traitement de maladies et de conditions d'origine immunologique, telles que le rejet de greffes de moëlle osseuse, d'organes ou de tissus. L'invention concerne également des compositions pharmaceutiques et des procédés d'utilisation.
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