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1. WO2002018320 - INHIBITORS OF $g(a)4 MEDIATED CELL ADHESION

Publication Number WO/2002/018320
Publication Date 07.03.2002
International Application No. PCT/US2001/026594
International Filing Date 27.08.2001
Chapter 2 Demand Filed 28.03.2002
IPC
C07C 233/87 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
64having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
81having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
82with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
87of a carbon skeleton containing six-membered aromatic rings
CPC
A61K 31/198
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
197the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
198Alpha-aminoacids, e.g. alanine, edetic acids [EDTA],
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 13/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
A61P 13/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
02of urine or of the urinary tract, e.g. urine acidifiers
Applicants
  • TANABE SEIYAKU CO., LTD. [JP]/[JP] (AllExceptUS)
  • KAWAGUCHI, Takayuki [JP]/[JP] (UsOnly)
  • NOMURA, Sumihiro [JP]/[JP] (UsOnly)
  • TSUKIMOTO, Mikiko [JP]/[JP] (UsOnly)
  • KUME, Toshiyuki [JP]/[JP] (UsOnly)
  • SIRCAR, Ila [US]/[US] (UsOnly)
Inventors
  • KAWAGUCHI, Takayuki
  • NOMURA, Sumihiro
  • TSUKIMOTO, Mikiko
  • KUME, Toshiyuki
  • SIRCAR, Ila
Agents
  • MURPHY Jr., Gerald M.
Priority Data
60/229,12831.08.2000US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) INHIBITORS OF $g(a)4 MEDIATED CELL ADHESION
(FR) INHIBITEURS DE L'ADHESION CELLULAIRE INDUITE PAR ALPHA 4
Abstract
(EN)
The present invention relates to a phenylalanine derivative of Formula (I) wherein X1 is a halogen atom, X2 is a halogen atom, Q is a CH2R- is a carboxyl group which may be esterified; or a pharmaceutically acceptable salt thereof.
(FR)
La présente invention concerne un dérivé de la phénylalanine représenté par la formule générale (I), dans laquelle X1 représente un atome d'halogène, X2 représente un atome d'halogène, Q représente un groupe CH2- ou un groupe (CH2)2-, Y représente un groupe alkyle en C1-6, et CO2R représente un groupe carboxyle pouvant être estérifié ; ou un sel pharmaceutiquement acceptable de ce dernier.
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