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1. WO2002017902 - GENE CONFERRING RESISTANCE TO THE ANTIBACTERIAL 4,5-DIHYDROXY-2-CYCLOPENTEN-1-ONE (DHCP), THE PROTEIN ENCODED BY SAME, AND APPLICATIONS THEREOF

Publication Number WO/2002/017902
Publication Date 07.03.2002
International Application No. PCT/US2001/026961
International Filing Date 29.08.2001
Chapter 2 Demand Filed 22.02.2002
IPC
C07K 14/245 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195from bacteria
24from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
245Escherichia (G)
CPC
A61P 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
C07K 14/245
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195from bacteria
24from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
245Escherichia (G)
Y02A 50/30
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
50in human health protection, e.g. against extreme weather
30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applicants
  • TAKARA BIO INC. [JP]/[JP] (AllExceptUS)
  • INOUYE, Masayori [US]/[US] (UsOnly)
  • PHADTARE, Sangita [US]/[US] (UsOnly)
  • YAMANAKA, Kunitoshi [JP]/[JP] (UsOnly)
  • KATO, Ikunoshin [JP]/[JP] (UsOnly)
Inventors
  • INOUYE, Masayori
  • PHADTARE, Sangita
  • YAMANAKA, Kunitoshi
  • KATO, Ikunoshin
Agents
  • DONATIELLO, Guy, T.
Priority Data
60/228,72729.08.2000US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) GENE CONFERRING RESISTANCE TO THE ANTIBACTERIAL 4,5-DIHYDROXY-2-CYCLOPENTEN-1-ONE (DHCP), THE PROTEIN ENCODED BY SAME, AND APPLICATIONS THEREOF
(FR) GENE CONFERANT DE LA RESISTANCE A L'ACTIVITE ANTIBACTERIENNE DE 4,5-DIHYDROXY-2-CYCLOPENTENE-1-ONE (DHCP), PROTEINE CODEE PAR CELUI-CI, ET SES APPLICATIONS
Abstract
(EN)
The invention relates to a gene, dep, which confers resistance to the antibacterial activity of 4,5-dihydroxy-2-cyclopenten-1-one (DHCP). The invention further relates to the putative protein encoded by dep, which is a hydrophobic, transmembrane efflux protein specific for DHCP. The inventin further relates to plasmids containing the dep gene, and to bacterial cells expressing dep. Furthermore, the invention provides applications for use in conferring resistance to antibacterial activity in organisms. The dep gene can be used to identify compounds which inhibit the efflux activity responsible for the resistance to DHCP or to compounds which are functionally equivalent to DHCP.
(FR)
L'invention concerne un gène, <i>dep</i>, qui confère de la résistance à l'activité antibactérienne de 4,5-dihydroxy-2-cyclopentène-1-one (DHCP). L'invention concerne également la protéine putative codée par <i>dep</i>, qui est une protéine hydrophobe d'efflux transmembranaire, spécifique de DHCP. La présente invention porte aussi sur les plasmides contenant le gène <i>dep</i>, sur les cellules bactériennes exprimant <i>dep</i>, ainsi que sur des applications visant à conférer de la résistance à l'activité antibactérienne dans les organismes. Le gène <i>dep</i> peut être utilisé pour identifier des composés qui inhibent l'activité d'efflux responsable de la résistance à DHCP ou à des composés équivalents à DHCP quant à leur fonction.
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