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1. WO2002017901 - OXIDIZED FORMS OF RETINOIC ACID AS LIGANDS FOR PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA

Publication Number WO/2002/017901
Publication Date 07.03.2002
International Application No. PCT/US2001/041934
International Filing Date 30.08.2001
Chapter 2 Demand Filed 19.03.2002
IPC
A61K 31/203 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
20having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid
203Retinoic acids
A61K 38/28 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
22Hormones
28Insulins
G01N 33/566 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
566using specific carrier or receptor proteins as ligand binding reagent
CPC
A61K 31/203
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
20having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
203Retinoic acids ; Salts thereof
A61K 38/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
22Hormones
28Insulins
A61P 3/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
A61P 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 9/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applicants
  • THE BRIGHAM AND WOMEN'S HOSPITAL, INC. [US]/[US]
Inventors
  • PLUTZKY, Jorge
  • ZIOUZENKOVA, Ouliana
Agents
  • SANZO, Michael, A.
Priority Data
60/228,76330.08.2000US
60/246,06707.11.2000US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) OXIDIZED FORMS OF RETINOIC ACID AS LIGANDS FOR PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA
(FR) FORMES OXYDEES D'ACIDE RETINOIQUE EN TANT QUE LIGANDS DU RECEPTEUR-GAMMA ACTIVE PAR LE PROLIFERATEUR DE PEROXISOME
Abstract
(EN)
The present invention is directed to certain oxidized forms of retinoic acid and their precursors that have been found to be effective in treating conditions that respond to agents that bind to and activate the human peroxisome proliferator activated receptor-gamma. Specific compounds include oxidized all-trans retinoic acid; oxidized 9-cis retinoic acid; and reduced 4-oxo-retinoic acid. The compounds may be used in treating a number of diseases or conditions including diabetes, low body weight, atherosclerosis, and certain forms of cancer.
(FR)
L'invention concerne certaines formes oxydées d'acide rétinoïque et leur précurseur dont on a découvert l'efficacité pour traiter des états sensibles à des agents se fixant au récepteur-gamma activé par le proliférateur de péroxisome humain et activant ce récepteur-gamma. Des composés spécifiques consistent en des acides trans-rétinoïques oxydés, des acides 9-cis rétinoïques oxydés et des acides 4-oxo-rétinoïques réduits. On peut utiliser ces composés pour traiter plusieurs maladies ou états, y compris le diabète, l'insuffisance de poids, l'athérosclérose et certaines formes de cancer.
Also published as
Latest bibliographic data on file with the International Bureau