Search International and National Patent Collections

1. (WO2002008445) DRUG SCREENING USING YEAST CELLS

Pub. No.:    WO/2002/008445    International Application No.:    PCT/EP2001/007984
Publication Date: Jan 31, 2002 International Filing Date: Jul 11, 2001
IPC: C12Q 1/02
Applicants: MYOCONTRACT PHARMACEUTICAL RESEARCH AG
MEIER, Thomas
JAUSLIN, Matthias
NUOFFER, Claude, A.
Inventors: MEIER, Thomas
JAUSLIN, Matthias
NUOFFER, Claude, A.
Title: DRUG SCREENING USING YEAST CELLS
Abstract:
The present invention provides a method wherein yeast mutants deficient in the expression of the yeast homolog of frataxin are applied for the identification and/or evaluation of pharmaceutically active compounds. The invention concerns especially a method wherein the yeast strain W303-1B/Δydl120w::KanR is applied for the identification and/or evaluation of chemical and biochemical compounds that protect W303-1B/Δydl120w::KanR yeast from chemical stress. Furthermore, the invention concerns the application of said method in new cell-based assays to be used for drug screening.