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1. (WO2002008260) BSTP-ECG1 PROTEIN AND RELATED REAGENTS AND METHODS OF USE THEREOF

Pub. No.:    WO/2002/008260    International Application No.:    PCT/US2001/023439
Publication Date: Jan 31, 2002 International Filing Date: Jul 26, 2001
IPC: A61K 38/00
C07K 14/47
C07K 16/18
Applicants: STANFORD UNIVERSITY
APPLIED GENOMICS, INC.
BOTSTEIN, David
BROWN, Patrick, O.
PEROU, Chuck
ROSS, Douglas
SEITZ, Rob
Inventors: BOTSTEIN, David
BROWN, Patrick, O.
PEROU, Chuck
ROSS, Douglas
SEITZ, Rob
Title: BSTP-ECG1 PROTEIN AND RELATED REAGENTS AND METHODS OF USE THEREOF
Abstract:
The invention provides polypeptides (BSTP-ECG1) and polynucleotides which identify and encode BSTP-ECG1 and fragments and variants thereof. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. In addition, the invention provides methods for treating or preventing disorders of cell proliferation, particularly breast cancer, by administering a pharmaceutical composition comprising a polypeptide, polynucleotide, or antibody of the invention. The invention also provides methods of classifying diseases, particularly breast cancer, by detecting expression of BSTP-ECG1 or of a polynucleotide encoding BSTP-ECG1, and of providing diagnostic, prognostic, and/or predictive information for a patient based on the detection and/or measurement of BSTP-ECG1 or of a polynucleotide encoding BSTP-ECG1.