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1. WO2002008239 - NOVEL DISACCHARIDES WITH ANTI-ARTHRITIC ACTION

Publication Number WO/2002/008239
Publication Date 31.01.2002
International Application No. PCT/ES2001/000265
International Filing Date 05.07.2001
Chapter 2 Demand Filed 06.02.2002
IPC
C07H 3/06 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
3Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
06Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
C07H 7/033 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
7Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
02Acyclic radicals
033Uronic acids
C07H 11/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
11Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
CPC
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 7/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
C07H 11/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
11Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
C07H 3/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
3Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
06Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
C07H 7/033
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
7Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
02Acyclic radicals
033Uronic acids
Applicants
  • BIOIBERICA, S.A. [ES]/[ES] (AllExceptUS)
  • VILA PAHI, Francisco Javier [ES]/[ES] (UsOnly)
  • FLORES SALGADO, Francesc [ES]/[ES] (UsOnly)
  • RUHI ROURA, Ramon [ES]/[ES] (UsOnly)
  • ARNAU PASTOR, Narcís [ES]/[ES] (UsOnly)
Inventors
  • VILA PAHI, Francisco Javier
  • FLORES SALGADO, Francesc
  • RUHI ROURA, Ramon
  • ARNAU PASTOR, Narcís
Agents
  • SUGRAÑES MOLINE, Pedro
  • SUGRAÑES-VERDONCES-FERREGÜELA
Priority Data
P 20000174113.07.2000ES
Publication Language Spanish (es)
Filing Language Spanish (ES)
Designated States
Title
(EN) NOVEL DISACCHARIDES WITH ANTI-ARTHRITIC ACTION
(ES) NUEVOS DISACARIDOS CON ACCION ANTIARTROSICA
(FR) NOUVEAUX DISACCHARIDES A ACTION ANTI-ARTHROSIQUE
Abstract
(EN) The invention relates to novel disaccharides of formula (I), wherein R1 is selected from the group consisting of hydrogen, linear or branched (C1-C4) alkyl, phenylalkyl with less than ten carbon atoms and -COCH3; R2 is selected from the group consisting of hydrogen, - COCH3 and SO3M; R3 is selected from the group consisting of hydrogen, linear or branched (C1-C4) alkyl, phenylalkyl with less than ten carbon atoms, - COCH3 and y -COPh, Ph being phenyl; G is selected from amongst - COOR4 and -COOM, R4 is selected from the group consisting of hydrogen, (C1-C2)-alkyl and arylalkyl with less than sixteen carbon atom; A is selected from the group consisting of hydrogen, -SO3H, -SO3M and -COCH3; B is selected from the group consisting of hydrogen, -SO3H, -SO3M and -COCH3, wherein either A or B are necessarily either -SO3H or -SO3M, M being a an organic or metallic cation. Said compounds can be used as anti-arthritic agents, anti-inflammatory agents or to control blood coagulation.
(ES) La presente invención se refiere a nuevos disacáridos de fórmula (I), donde R1 se selecciona del grupo constituido por hidrógeno, (C1-C4)-alquilo lineal o ramificado, fenilalquilo de menos de diez átomos de carbono y -COCH3; R2 se selecciona del grupo constituido por hidrógeno, - COCH3 y SO3M; R3 se selecciona del grupo constituido por hidrógeno, (C1-C4)-alquilo lineal o ramificado, fenilalquilo de menos de diez átomos de carbono, - COCH3 y -COPh, siendo Ph fenilo; G se escoge entre - COOR4 y -COOM, seleccionándose R4 del grupo constituido por hidrógeno, (C1-C2)-alquilo y arilalquilo de menos de dieciseis átomos de carbono; A se selecciona del grupo constituido por hidrógeno, -SO3H, -SO3M y -COCH3; B se selecciona del grupo constituido por hidrógeno, -SO3H, -SO3M y -COCH3; en donde necesariamente o A o B son o bien -SO3H, o bien -SO3M, y siendo M es un catión orgánico o metálico. Dichos compuestos pueden ser utilizados como antiartrósicos, antiinflamatorios o para controlar la coagulación sanguínea.
(FR) La présente invention concerne de nouveaux disaccharides représentés par la formule générale (I), dans laquelle R1 représente un élément sélectionné dans le groupe comprenant un hydrogène, un alkyle (C1-C4) linéaire ou ramifié, un phénylalkyle comprenant moins de dix atomes de carbone et un -COCH3; R2 représente un élément sélectionné dans le groupe comprenant un hydrogène, un - COCH3 et un SO3M; R3 représente un élément sélectionné dans le groupe comprenant un hydrogène, un alkyle (C1-C4) linéaire ou ramifié, un phénylalkyle comprenant moins de dix atomes de carbone, un - COCH3 et un -COPh, Ph représentant un phényle; G représente un élément sélectionné dans le groupe comprenant un - COOR4 et un -COOM, R4 étant sélectionné dans le groupe comprenant un hydrogène, un alkyle (C1-C2) et un arylalkyle comprenant moins de seize atomes de carbone; A représente un élément sélectionné dans le groupe comprenant un hydrogène, un -SO3H, un -SO3M et un -COCH3; B représente un élément sélectionné dans le groupe comprenant un hydrogène, un -SO3H, un -SO3M et un -COCH3; A ou B représente nécessairement soit un -SO3H, soit un -SO3M, et M représentant un cation organique ou métallique. Ces composés peuvent être utilisés comme anti-arthrosiques, anti-inflammatoires ou pour réguler la coagulation sanguine.
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