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1. (WO2002008228) METHOD FOR THE MANUFACTURE OF ANAGRELIDE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/008228    International Application No.:    PCT/GB2001/003362
Publication Date: 31.01.2002 International Filing Date: 26.07.2001
Chapter 2 Demand Filed:    22.02.2002    
IPC:
C07D 487/04 (2006.01)
Applicants: SHIRE US INC [US/US]; 7900 Tanners Gate Drive, Suite 200, Florence, KY 41042 (US)
Inventors: LANG, Philip, Charles; (US).
SPENCER, Roxanne, Paula; (US).
YEH, Wen-Lung; (CA).
ROTH, Michael, Joseph; (CA)
Agent: WOODMAN, Derek; Frank B. Dehn & Co., 179 Queen Victoria Street, London EC4V 4EL (GB)
Priority Data:
09/625,962 26.07.2000 US
Title (EN) METHOD FOR THE MANUFACTURE OF ANAGRELIDE
(FR) PROCEDE DE PREPARATION D'ANAGRELIDE
Abstract: front page image
(EN)Methods are provided for making certain 6,7-dihaol-1,5-dihydroimidazo [2,1-b]quinazolin-2(3H)-ones from 2,3-dihalobenzaldehydes. A method is also provided for making the intermediate ethyl N-(2,3-dihalo-6-nitrobenzyl)glycines from 2,3-dihalobenzaldehydes and for reducing the glycine compounds using either SnC1¿2? or a specially defined catalyst. A cyclization method to form the desired 6,7-dihalo-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-ones from the corresponding iminquinazoline compounds is further provided. These methods are particularly suitable in the manufacture of Anagrelide base.
(FR)L'invention concerne des procédés destinés à préparer certaines 6,7-dihalo-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-ones à partir de 2,3-dihalobenzaldéhydes. L'invention se rapporte également à un procédé destiné à préparer les produits intermédiaires éthyl-N-(2,3-dihalo-6-nitrobenzyl)glycines à partir de 2,3-dihalobenzaldéhydes et à réduire les composés glycine avec du SnCl¿2? ou un catalyseur spécialement défini. L'invention concerne en outre un procédé de cyclisation destiné à former les 6,7-dihalo-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-ones souhaitées à partir des composés iminoquinazoline correspondants. Ces procédés conviennent notamment à la préparation d'une base anagrélide.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)