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1. (WO2002008202) ALPHA AMINO ACID DERIVATIVES--INHIBITORS OF LEUKOCYTE ADHESION MEDIATED BY VLA-4
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/008202    International Application No.:    PCT/US2001/023075
Publication Date: 31.01.2002 International Filing Date: 20.07.2001
Chapter 2 Demand Filed:    09.01.2002    
IPC:
C07D 239/48 (2006.01), C07D 239/52 (2006.01), C07D 401/12 (2006.01), C07D 417/12 (2006.01)
Applicants: ELAN PHARMACEUTICALS, INC. [US/US]; 800 Gateway Blvd. South San Francisco, CA 94080 (US).
WYETH [US/US]; 5 Giraldi Farms Madison, NJ 07940 (US)
Inventors: KONRADI, Andrei, W.; (US).
PLEISS, Michael, A.; (US).
THORSETT, Eugene, D.; (US).
ASHWELL, Susan; (US).
WELMAKER, Gregory, S.; (US).
KREFT, Anthony; (US).
SARANTAKIS, Dimitrios; (US).
DRESSEN, Darren, B.; (US).
GRANT, Francine, S.; (US).
SEMKO, Christopher; (US).
XU, Ying-Zi; (US)
Agent: SWISS, Gerald, F.; Burns, Doane, Swecker & Mathis, L.L.P. P.O. BOX 1404 Alexandria, VA 22313-1404 (US)
Priority Data:
60/220,132 21.07.2000 US
Title (EN) ALPHA AMINO ACID DERIVATIVES--INHIBITORS OF LEUKOCYTE ADHESION MEDIATED BY VLA-4
(FR) DERIVES D'ACIDE ALPHA-AMINE, UTILISES COMME INHIBITEURS DE L'ADHESION LEUCOCYTAIRE A MEDIATION PAR VLA-4
Abstract: front page image
(EN)Disclosed are certain alpha amino acid compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
(FR)Cette invention se rapporte à certains composés d'acide alpha-aminé qui fixent VLA-4. Certains de ces composés inhibent également l'adhésion leucocytaire, et, notamment, l'adhésion leucocytaire à médiation par VLA-4. Ces composés sont utiles pour traiter chez des mammifères, notamment chez l'homme, des maladies inflammatoires telles que l'asthme, la maladie d'Alzheimer, l'athérosclérose, le syndrome démentiel lié au SIDA, le diabète, les maladies intestinales inflammatoires, la polyarthrite rhumatoïde, la transplantation des tissus, les métastases tumorales et l'ischémie myocardique. Ces composés peuvent également être administrés pour traiter des maladies cérébrales inflammatoires telles que la sclérose en plaques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)