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Machine translation
1. (WO2002008201) BETA-AMINO ACID DERIVATIVES-INHIBITORS OF LEUKOCYTE ADHESION MEDIATED BY VLA-4
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/008201    International Application No.:    PCT/US2001/023071
Publication Date: 31.01.2002 International Filing Date: 20.07.2001
Chapter 2 Demand Filed:    09.01.2002    
IPC:
C07D 239/48 (2006.01), C07D 239/69 (2006.01), C07D 285/10 (2006.01), C07D 401/12 (2006.01)
Applicants: ELAN PHARMACEUTICALS, INC. [US/US]; 800 Gateway Blvd. South San Francisco, CA 94080 (US).
WYETH [US/US]; Five Giralda Farms Madison, NJ 07940 (US)
Inventors: KONRADI, Andrei W.; (US).
PLEISS, Michael A.; (US).
THORSETT, Eugene D.; (US).
ASHWELL, Susan; (US).
WELMAKER, Gregory S.; (US).
KREFT, Anthony; (US).
SARANTAKIS, Dimitrios; (US).
GRANT, Francine S.; (US).
DRESSEN, Darren B.; (US).
SEMKO, Christopher; (US).
XU, Ying-Zi; (US).
STAPPENBECK, Frank; (US)
Agent: SWISS, Gerald F.; Burns, Doane, Swecker & Mathis, L.L.P. P.O. Box 1404 Alexandria, VA 22313-1404 (US)
Priority Data:
60/220,118 21.07.2000 US
Title (EN) BETA-AMINO ACID DERIVATIVES-INHIBITORS OF LEUKOCYTE ADHESION MEDIATED BY VLA-4
(FR) DERIVES DE L'ACIDE BETA-AMINO INHIBITEURS DE L'ADHESION DES LEUCOCYTES INDUITE PAR VLA-4
Abstract: front page image
(EN)Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
(FR)L'invention porte sur des composés qui se lient à VLA-4. Certains de ces composés inhibent également l'adhésion des leucocytes, et notamment, l'adhésion des leucocytes induite par VLA-4. Ces composés sont utiles dans le traitement des maladies inflammatoires telles que l'asthme, la maladie d'Alzheimer, l'athérosclérose, le syndrome démentiel lié au SIDA, les diabètes, les affections intestinales inflammatoires, l'arthrite rhumatoïde, la transplantation des tissus, la métastase et l'ischémie myocardique. Les composés peuvent être également administrés dans le traitement des affections cérébrales inflammatoires telles que la sclérose en plaques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)