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1. (WO2002007763) HELICOBACTER PYLORI WITH MODIFIED LIPOPOLYSACCHARIDE BIOSYNTHESIS

Pub. No.:    WO/2002/007763    International Application No.:    PCT/IB2001/001536
Publication Date: Jan 31, 2002 International Filing Date: Jul 12, 2001
IPC: C07K 14/205
C12N 9/10
Applicants: CHIRON S.P.A.
DEL GIUDICE, Guiseppe
RAPPUOLI, Rino
Inventors: DEL GIUDICE, Guiseppe
RAPPUOLI, Rino
Title: HELICOBACTER PYLORI WITH MODIFIED LIPOPOLYSACCHARIDE BIOSYNTHESIS
Abstract:
Helicobacter pylori can be manipulated at a genetic level to prevent the synthesis of auto-reactive LPS, without destroying the physical integrity or function of the bacterial outer membrane. The bacterium is particularly useful for preparing cellular vaccines which do not induce antibodies which cross-react with self epitopes. Cellular H.pylori vaccines are provided which comprise mutant H.pylori which either does not express LPS or, preferably, expresses a mutant form of LPS.