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1. WO2002007757 - PREVENTION AND TREATMENT OF SEXUAL AROUSAL DISORDERS

Publication Number WO/2002/007757
Publication Date 31.01.2002
International Application No. PCT/US2001/022970
International Filing Date 19.07.2001
Chapter 2 Demand Filed 05.12.2001
IPC
A61K 38/18 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
18Growth factors; Growth regulators
A61K 48/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
CPC
A61K 38/1825
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
18Growth factors; Growth regulators
1825Fibroblast growth factor [FGF]
A61K 38/185
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
18Growth factors; Growth regulators
185Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
A61K 38/1866
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
18Growth factors; Growth regulators
1858Platelet-derived growth factor [PDGF]
1866Vascular endothelial growth factor [VEGF]
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61P 15/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
Applicants
  • LUE, Tom, F. [US]/[US]
Inventors
  • LUE, Tom, F.
  • LIN, Ching-Shwun
  • KAN, Yuet, W.
Agents
  • CHEN, Peng
Priority Data
60/220,03121.07.2000US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) PREVENTION AND TREATMENT OF SEXUAL AROUSAL DISORDERS
(FR) METHODES ET COMPOSITIONS DESTINEES A PREVENIR ET TRAITER LA DYSERECTION CHEZ L'HOMME ET LES TROUBLES DE L'EXCITATION SEXUELLE CHEZ LA FEMME
Abstract
(EN) This invention relates generally to the field of urology. In particular, the invention provides a method for preventing or treating male erectile dysfunction or female sexual arousal disorder, which method comprises administering an effective amount of vascular endothelial growth factor (VEGF), brain-derived neurotrophic factor (BDNF), basic fibroblast growth factor (bFGF), or a functional derivative or fragment thereof, or a nucleic acid encoding said VEGF, BDNF or bFGF, or functional derivative or fragment thereof, or an agent that enhances production and/or erection or sexual arousal stimulating function of said VEGF or BDNF or bFGF to a mammal, wherein such prevention or treatment is desirable, thereby preventing or treating said male erectile dysfunction of female sexual arousal disorder in said mammal. Combinations, combinatorial methods and kits for preventing or treating male erectile dysfunction or female sexual arousal disorder are also provided.
(FR) De manière générale, l'invention concerne le domaine de l'urologie. Plus particulièrement, l'invention concerne une méthode destinée à prévenir ou traiter la dysérection chez l'homme et les troubles de l'excitation sexuelle chez la femme. Cette méthode consiste à administrer, à un mammifère nécessitant un tel traitement, une dose efficace d'un facteur de croissance endothéliale vasculaire (VEGF), d'un facteur neurotrophique dérivé du cerveau (BDNF), d'un facteur de croissance fibroblastique basique (bFGF) ou d'un dérivé ou fragment fonctionnel desdits facteurs, d'un acide nucléique codant pour ces facteurs VEGF, BDNF ou bFGF ou pour ce dérivé ou fragment, ou d'un agent renforçant la production et/ou la fonction stimulatrice de l'érection ou de l'excitation sexuelle desdits facteurs en vue de prévenir ou traiter la dysérection ou les troubles de l'excitation chez ce mammifère. L'invention concerne également des combinaisons, des méthodes combinatoires et des trousses permettant de prévenir ou traiter la dysérection chez l'homme ou les troubles de l'excitation sexuelle chez la femme.
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