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1. WO2002007727 - USE OF PYRIDAZINO(4,5-)INDOLE-1-ACETAMIDE DERIVATIVES FOR PREPARING MEDICINES FOR TREATING PATHOLOGIES RELATED TO THE DYSFUNCTION OF PERIPHERAL BENZODIAZEPIN RECEPTORS

Publication Number WO/2002/007727
Publication Date 31.01.2002
International Application No. PCT/FR2001/002369
International Filing Date 20.07.2001
Chapter 2 Demand Filed 11.02.2002
IPC
A61K 31/5025 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
50Pyridazines; Hydrogenated pyridazines
5025ortho- or peri-condensed with heterocyclic ring systems
CPC
A61K 31/5025
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
50Pyridazines; Hydrogenated pyridazines
5025ortho- or peri-condensed with heterocyclic ring systems
A61P 13/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61P 25/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
02for peripheral neuropathies
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • SANOFI-SYNTHELABO [FR]/[FR] (AllExceptUS)
  • BARTSCH-LI, Régine [FR]/[FR] (UsOnly)
  • DUBOIS, Laurent [FR]/[FR] (UsOnly)
  • EVANNO, Yannick [FR]/[FR] (UsOnly)
  • FROISSANT, Jacques [FR]/[FR] (UsOnly)
  • GEORGE, Pascal [BE]/[FR] (UsOnly)
  • MARABOUT, Benoît [FR]/[FR] (UsOnly)
  • MARGUET, Franck [FR]/[FR] (UsOnly)
  • SEVRIN, Mireille [BE]/[FR] (UsOnly)
Inventors
  • BARTSCH-LI, Régine
  • DUBOIS, Laurent
  • EVANNO, Yannick
  • FROISSANT, Jacques
  • GEORGE, Pascal
  • MARABOUT, Benoît
  • MARGUET, Franck
  • SEVRIN, Mireille
Agents
  • LUDWIG, Jacques
Priority Data
00/0965524.07.2000FR
Publication Language French (fr)
Filing Language French (FR)
Designated States
Title
(EN) USE OF PYRIDAZINO(4,5-)INDOLE-1-ACETAMIDE DERIVATIVES FOR PREPARING MEDICINES FOR TREATING PATHOLOGIES RELATED TO THE DYSFUNCTION OF PERIPHERAL BENZODIAZEPIN RECEPTORS
(FR) UTILISATION DE DERIVES DE PYRIDAZINO (4, 5) INDOLE-1-ACETAMIDE POUR LA PREPARATION DE MEDICAMENTS DESTINES AU TRAITEMENT DES PATHOLOGIES LIEES AUX DYSFONCTIONNEMENTS DES RECEPTEURS DE TYPE PERIPHERIQUE AUX BENZODIAZEPINES
Abstract
(EN) The invention concerns the use of a compound, in the form of base or addition salt to an acid, corresponding the general formula (I) wherein: X represents a halogen atom; Y represents one or several atoms or groups selected among hydrogen, halogens and hydroxy, methyl and methoxy groups; R1 represents a hydrogen atom or an alkyl group; R2 represents a hydrogen atom, an alkyl group, a hydroxyalkyl group, a cycloalkyl group, a cycloalkyl-alkyl group, a phenyl group, a pyridinyl group or a phenylalkyl group, for preparing a medicine for preventing or treating a disease related to the dysfunction of peripheral benzodiazepin receptors
(FR) Utilisation d'un composé, à l'état de base ou de sel d'addition à un acide, répondant à la formule générale (I) dans laquelle X représente un atome d'halogène, Y représente un ou plusieurs atomes ou groupes choisis parmi l'hydrogène, les halogènes et les groupes hydroxy, méthyle et méthoxy, R1 représente un atome d'hydrogène ou un groupe alkyle, R2 représente un atome d'hydrogène, un groupe alkyle, un groupe hydroxyalkyle, un groupe cycloalkyle, un groupe cycloalkyl-alkyle, un groupe phényle, un groupe pyridinyle ou un groupe phénylalkyle, pour la préparation d'un médicament destiné à la prévention ou au traitement d'une maladie liée au dysfonctionnement des récepteurs de type périphérique aux benzodiazépines.
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