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1. (WO2002006463) REGULATION OF GENE EXPRESSION USING SINGLE-CHAIN, MONOMERIC, LIGAND DEPENDENT POLYPEPTIDE SWITCHES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/006463    International Application No.:    PCT/EP2001/008190
Publication Date: 24.01.2002 International Filing Date: 16.07.2001
Chapter 2 Demand Filed:    21.01.2002    
IPC:
C07K 14/47 (2006.01), C07K 14/72 (2006.01), C12N 15/63 (2006.01)
Applicants: NOVARTIS AG [CH/CH]; Lichtstrasse 35, CH-4056 Basel (CH) (AE, AG, AL, AM, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW only).
NOVARTIS PHARMA GMBH [AT/AT]; Brunner Strasse 59, A-1230 Vienna (AT) (AT only).
THE SCRIPPS RESEARCH INSTITUTE [US/US]; 10550 North Torrey Pines Road, La Jolla, CA 92037 (US) (For All Designated States Except US).
BEERLI, Roger [CH/CH]; (CH) (For US Only).
SCHOPFER, Ulrich [DE/DE]; (DE) (For US Only).
BARBAS, Carlos, F. [US/US]; (US) (For US Only)
Inventors: BEERLI, Roger; (CH).
SCHOPFER, Ulrich; (DE).
BARBAS, Carlos, F.; (US)
Agent: BECKER, Konrad; Novartis AG, Corporate Intellectual Property, Patent & Trademark Property, CH-4002 Basel (CH)
Priority Data:
09/619,063 18.07.2000 US
Title (EN) REGULATION OF GENE EXPRESSION USING SINGLE-CHAIN, MONOMERIC, LIGAND DEPENDENT POLYPEPTIDE SWITCHES
(FR) REGULATION D'EXPRESSION GENIQUE A L'AIDE DE COMMUTATEURS POLYPEPTIDIQUES MONOMERES A CHAINE UNIQUE DEPENDANT D'UN LIGAND
Abstract: front page image
(EN)Single chain, monomeric polypeptide gene switches are provided. The gene switches include ligand binding domains and at least one functional domain. Preferred functional domains are DNA binding domains and transcriptional regulating domains. Methods of regulating gene function using the switches are also provided.
(FR)L'invention concerne des commutateurs de gènes polypeptidiques monomères à chaîne unique. Ces commutateurs de gènes comprennent des domaines de liaison de ligand et au moins un domaine fonctionnel. Les domaines fonctionnels préférés sont les domaines de liaison d'ADN et les domaines de régulation transcriptionnelle. L'invention concerne également des méthodes de régulation de fonction génique utilisant lesdites commutateurs.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)