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1. WO2002006343 - COMPOSITION FOR TREATMENT OF AND METHOD OF MONITORING HEPATITIS C VIRUS USING INTERFERON-TAU

Publication Number WO/2002/006343
Publication Date 24.01.2002
International Application No. PCT/US2001/022976
International Filing Date 19.07.2001
Chapter 2 Demand Filed 19.02.2002
IPC
A61K 38/21 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
19Cytokines; Lymphokines; Interferons
21Interferons
CPC
A61K 38/21
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
19Cytokines; Lymphokines; Interferons
21Interferons ; [IFN]
Applicants
  • PEPGEN CORPORATION [US]/[US]
Inventors
  • SOKAWA, Yoshihiro
  • LIU, Chih-Ping
Agents
  • THROWER, Larry, W.
  • VOSSIUS & partner
Priority Data
2000-31716017.10.2000JP
60/219,12819.07.2000US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITION FOR TREATMENT OF AND METHOD OF MONITORING HEPATITIS C VIRUS USING INTERFERON-TAU
(FR) COMPOSITION DE TRAITEMENT/METHODE DE SURVEILLANCE DU VIRUS DE L'HEPATITE C UTILISANT L'INTERFERON-$G(T)
Abstract
(EN) A method of monitoring treatment of HCV by oral administration of ovine IFN-$g(t) is disclosed. The method includes measuring the blood levels of 2', 5'-oligoadenylate synthetase prior to and after such oral administration, and if necessary, adjusting the dose of IFN-$g(t) until a measurable increase in blood 2', 5'-oligoadenylate synthetase level, relative to the level observed prior to administration, is observed. Also disclosed are oral-delivery compositions for use in treating HCV in an HCV-infected patient comprising ovine IFN-$g(t), in a dosage effective to stimulate bloodstream levels of 2', 5'-oligoadenylate synthetase.
(FR) La présente invention concerne une méthode de surveillance du traitement du virus de l'hépatite (VHC), consistant à administrer par voie orale de l'interféron-$g(t) (IFN-$g(t)) ovin. Cette méthode consiste à mesurer les taux de 2', 5'-oligoadénylate synthétase dans le sang avant et après l'administration par voie orale, et si nécessaire, à ajuster la dose de IFN-$g(t) jusqu'à ce qu'une augmentation mesurable de 2', 5'-oligoadénylate synthétase dans le sang, par rapport aux taux avant l'administration, soit observée. Par ailleurs, cette invention concerne des compositions à administration par voie orale, contenant un IFN-$g(t) ovin, et destinées au traitement d'un patient infecté par VHC, selon un dosage efficace pour stimuler les taux de 2', 5'-oligoadénylate synthétase dans la circulation sanguine.
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