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1. (WO2002006324) ANTIFUNGAL AND/OR ANTIBACTERIAL PEPTIDES, PREPARATION METHODS AND COMPOSITION CONTAINING SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/006324    International Application No.:    PCT/FR2001/002164
Publication Date: 24.01.2002 International Filing Date: 05.07.2001
Chapter 2 Demand Filed:    12.02.2002    
IPC:
A01N 37/46 (2006.01), A01N 63/02 (2006.01), A61K 38/00 (2006.01), C07K 14/435 (2006.01)
Applicants: ENTOMED (S.A.) [FR/FR]; Rue Tobias Stimmer F-67400 Illkirch (FR) (For All Designated States Except US).
DIMARCQ, Jean-Luc [FR/FR]; (FR) (For US Only).
LEGRAIN, Michèle [FR/FR]; (FR) (For US Only).
MENIN, Laure [--/CH]; (CH) (For US Only)
Inventors: DIMARCQ, Jean-Luc; (FR).
LEGRAIN, Michèle; (FR).
MENIN, Laure; (CH)
Agent: BREESE, Pierre; Breese-Majerowicz 3, avenue de l'Opéra F-75001 Paris (FR)
Priority Data:
00/09248 13.07.2000 FR
00/11949 19.09.2000 FR
Title (EN) ANTIFUNGAL AND/OR ANTIBACTERIAL PEPTIDES, PREPARATION METHODS AND COMPOSITION CONTAINING SAME
(FR) PEPTIDES ANTIFONGIQUES ET/OU ANTIBACTERIENS, LEURS PREPARATIONS ET LES COMPOSITIONS LES CONTENANT
Abstract: front page image
(EN)The invention concerns peptides derived from heliomicine by substitution of one or several amino acids, characterised in that said peptides correspond to formula (I): X¿1?, X¿2?, X¿3?, X¿4?, X¿5?, X¿6?, C¿7?, X¿8?, X¿9?, X¿10?, X¿11?, X¿12?, X¿13?, X¿14?, X¿15?, X¿16?, X¿17?, C¿18?, X¿19?, X¿20?, X¿21?, C¿22? X¿23?, X¿24?, X¿25?, X¿26?, X¿27?, X¿28?, X¿29?, X¿30?, X¿31?, X¿32?, X¿33?, X¿34?, X¿35?, X¿36?, X¿37?, X¿38?, X¿39?, C¿40?, X¿41?, C¿42?, X¿43?, X¿44? wherein: X¿1?, X¿17?, X¿21? X¿43? are amino acids; X¿16?, X¿44? are small polar amino acids; X¿19? is a large polar amino acid; X¿36? is a small or lightly hydrophobic amino acid; X¿38? is a lightly hydrophobic or small amino acid; said substitutions being such that: at least one of X¿1?, X¿17?, X¿21?, X¿43? is a basic or polar, advantageously large polar amino acid, and/or at least one of the amino acids X¿16?, X¿44? is a basic amino acid or a large polar amino acid, and/or X¿19? is a basic amino acid, and/or at least one of the amino acids X¿36?, X¿38? is a strongly hydrophobic amino acid. The invention also concerns antifungal and/or antibacterial compositions comprising at least one of said peptides.
(FR)La présente invention concerne des peptides dérivés de l'héliomicine par substitution de un à plusieurs acides aminés, caractérisé en ce que lesdits peptides répondent à la formule (I): X¿1?, X¿2?, X¿3?, X¿4?, X¿5?, X¿6?, X¿7?, X¿8?, X¿9?, X¿10?, X¿11?, X¿12?, X¿13?, X¿14?, X¿15?, X¿16?, X¿17?, X¿18?, X¿19?, X¿20?, X¿21?, X¿22?, X¿23?, X¿24?, X¿25?, X¿26?, X¿27?, X¿28?, X¿29?, X¿30?, X¿31?, X¿32?, X¿33?, X¿34?, X¿35?, X¿36?, X¿37?, X¿38?, X¿39?, X¿40?, X¿41?, X¿42?, X¿43?, X¿44?, dans laquelle: X¿1?, X¿17?, X¿43? sont des acides aminés acides, X¿16?, X¿44? sont des acides aminés polaires petits, X¿19? est un acide aminé polaire large, X¿36? est un acide aminé petit ou faiblement hydrophobe X¿38? est un acide aminé faiblement hydrophobe ou petit, lesdites substitutions étant telles que: l'un au moins des X¿1?, X¿17?, X¿21?, X¿43? est un acide aminé basique ou polaire avantageusement polaire large, et/ou l'un au moins des acides aminés X¿16?, X¿44? est un acide aminé basique ou un acide aminé polaire large, et/ou X¿19? est un acide aminé basique, et/ou l'un au moins des acides aminés X¿36?, X¿38? est un acide aminé fortement hydrophobe. L'invention concerne aussi des compositions antifongiques et/ou antimicrobiennes comprenant au moins un desdits peptides.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: French (FR)
Filing Language: French (FR)