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Machine translation
1. (WO2002006283) IMPROVED PREPARATION OF (4R, 5S, 6S)-3-(((2R,3R)-2-((((S)-2-AMINO-3-METHYL-1-OXOBUTYL)METHYL)TETRAHYDRO-3-FURANYL)THIO)-6-((R)-1-HYDROXYETHYL)-4-METHYL-7-OXO-1-AZABICYCLO(3.2.0)HEPT-2-ENE-2-CARBOXYLIC ACID
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/006283    International Application No.:    PCT/US2001/021721
Publication Date: 24.01.2002 International Filing Date: 10.07.2001
Chapter 2 Demand Filed:    28.01.2002    
IPC:
C07D 477/20 (2006.01)
Applicants: WYETH [US/US]; Five Giralda Farms, Madison, NJ 07940 (US)
Inventors: MANSOUR, Tarek; (US).
SUM, Phaik-Eng; (US).
LIN, Yang-I; (US).
LI, Zhong; (US)
Agent: BERG, Egon, E.; Wyeth, Patent Law Department, Five Giralda Farms, Madison, NJ 07940 (US)
Priority Data:
60/217,925 13.07.2000 US
Title (EN) IMPROVED PREPARATION OF (4R, 5S, 6S)-3-(((2R,3R)-2-((((S)-2-AMINO-3-METHYL-1-OXOBUTYL)METHYL)TETRAHYDRO-3-FURANYL)THIO)-6-((R)-1-HYDROXYETHYL)-4-METHYL-7-OXO-1-AZABICYCLO(3.2.0)HEPT-2-ENE-2-CARBOXYLIC ACID
(FR) PREPARATION AMELIOREE DE (4R, 5S, 6S)-3-[[(2R,3R)-2-[[[(S)-2-AMINO-3-METHYL-1-OXOBUTYL]METHYL]TETRAHYDRO-3-FURANYL]THIO]-6-[(R)-1-HYDROXYETHYL]-4-METHYL-7-OXO-1-AZABICYCLO[3.2.0]HEPT-2-ENE-ACIDE 2-CARBOXYLIQUE
Abstract: front page image
(EN)The invention is a process improvement for producing the carbapenem antibacterial agent (4R, 5S, 6S)-3-[[(2R,3R)-2-[[[(S)-2-amino-3-methyl-1-oxobutyl]amino]methyl]tetrahydro-3-furanyl]thio]-6-[(R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid by hydrogenation of 4-nitrobenzyl (4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-3-{[(2R,3R)-2-({[(2S)-3-methyl-2-({[(4-nitrobenzyl)oxy]carbonyl}amino)butanoyl]amino}methyl)-tetrahydrofuran-3-yl]thio}-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate in a biphasic solvent mixture comprising a water portion and an organic solvent portion, not containing an acid acceptor. Separating the water portion from the organic portion and isolating (4R, 5S, 6S)-3-[[(2R,3R)-2-[[[(S)-2-amino-3-methyl-1-oxobutyl]amino]methyl]tetrahydro-3-furanyl]thio]-6-[(R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid from the separated water portion by lyophilization or reverse osmosis.
(FR)La présente invention concerne l'amélioration d'un processus de production de l'agent antibactérien carbapenem (4R, 5S, 6S)-3-[[(2R,3R)-2-[[[(S)-2-amino-3-méthyl-1-oxobutyl]amino]méthyl]tétrahydro-3-furanyl]thio]-6-[(R)-1-hydroxyéthyl]-4-méthyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ène-acide 2-carboxylique par hydrogénation de 4-nitrobenzyle (4R,5S,6S)-6-[(1R)-1-hydroxyéthyl]-4-méthyl-3-{[(2R,3R)-2-({[(2S)-3-méthyl-2-({[(4-nitrobenzyl)oxy]carbonyl}amino)butanoyl]amino}méthyl)-tetrahydrofuran-3-yl]thio}-7-oxo-1-azabicyclo[3.2.0]hept-2-ène-2-carboxylate dans un mélange de solvants biphasique comprenant une part d'eau et une part de solvant organique, et ne contenant pas un accepteur d'acide. Ce processus consiste à séparer la part d'eau de la part de solvant organique et à isoler (4R, 5S, 6S)-3-[[(2R,3R)-2-[[[(S)-2-amino-3-méthyl-1-oxobutyl]amino]méthyl]tétrahydro-3-furanyl]thio]-6-[(R)-1-hydroxyéthyl]-4-méthyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ène-acide 2-carboxylique de la part d'eau séparée par lyophilisation ou osmose inverse.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)