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1. (WO2002006272) POLYFLUOROALKYLTRIAZOLE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/006272    International Application No.:    PCT/FR2001/002315
Publication Date: 24.01.2002 International Filing Date: 17.07.2001
Chapter 2 Demand Filed:    21.01.2002    
IPC:
C07D 249/12 (2006.01), C07D 401/12 (2006.01), C07D 401/14 (2006.01), C07D 405/14 (2006.01), C07D 409/14 (2006.01), C07D 417/14 (2006.01)
Applicants: SANOFI-SYNTHELABO [FR/FR]; 174 avenue de France, F-75013 Paris (FR) (For All Designated States Except US).
COURTEMANCHE, Gilles [FR/FR]; (FR) (For US Only).
CRESPIN, Olivier [FR/FR]; (FR) (For US Only).
PASCAL, Cécile [FR/FR]; (FR) (For US Only)
Inventors: COURTEMANCHE, Gilles; (FR).
CRESPIN, Olivier; (FR).
PASCAL, Cécile; (FR)
Agent: KUGEL, Dominique; Sanofi-Synthelabo, 174 Avenue de France, F-75013 Paris (FR)
Priority Data:
00/09418 18.07.2000 FR
Title (EN) POLYFLUOROALKYLTRIAZOLE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF
(FR) DERIVES DE POLYFLUOROALKYLTRIAZOLE, LEUR PREPARATION ET LEUR UTILISATION EN THERAPEUTIQUE
Abstract: front page image
(EN)The invention concerns compounds of general formula (I), wherein: R1 is a group of formula CnHxFy, where n = 1 or 2, x = 0 to 4, y = 1 to 5 and x+y = 2n+1; R represents a C¿2?-C¿4? alkenyl, phenyl, thienyl, furyl, pyridyl, imidazolyl, thiazolyl, pyranyl or dihydropyranyl group, optionally substituted by one or two R3 groups; R2 and R3, independently of each other, represent a hydrogen atom, a halogen atom, a C¿1?-C¿4? alkyl, C¿1?-C¿4? alkoxy, a hydroxy, an amino, a cyano, a nitro, a C¿1?-C¿4? alkylthio, a SO¿2?NH¿2? or a hydroxymethyl group; and their salts, N-oxides and hydrates. The invention has therapeutic applications.
(FR)Composés de formule générale (I), dans laquelle R1 est un groupe de formule CnHxFy, où n = 1 ou 2, x = 0 à 4, y = 1 à 5 et x+y = 2n+1; R représente un groupe C¿2-4? alkényle, phényle, thiényle, furyle, pyridyle, imidazolyle, thiazolyle, pyranyle ou dihydropyranyle, éventuellement substitué par un ou deux groupes R3; R2 et R3 représente, indépendamment l'un de l'autre, un atome d'hydrogène, un atome d'halogène, un groupe C¿1-4? alkyle, C¿1-4? alcoxy, un hydroxy un amino, un cyano, un nitro, un C¿1-4? alkythio, un SO¿2?NH¿2? ou un hydroxyméthyle; et ses sels, N-oxydes et hydrates. Application en thérapeutique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: French (FR)
Filing Language: French (FR)