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Pub. No.:    WO/2002/005849    International Application No.:    PCT/ZA2001/000100
Publication Date: 24.01.2002 International Filing Date: 19.07.2001
Chapter 2 Demand Filed:    18.02.2002    
A01N 63/02 (2006.01), A61K 31/201 (2006.01), A61K 31/202 (2006.01), A61K 31/7052 (2006.01), A61K 33/00 (2006.01), A61K 39/395 (2006.01), A61K 45/06 (2006.01), A61K 47/00 (2006.01), A61K 47/12 (2006.01), A61K 47/14 (2006.01)
Applicants: PITMY INTERNATIONAL N.V. [NL/NL]; Kaya Gob Nicolaas Debrot 33 Bonaire (AN) (For All Designated States Except US).
MEYER, Petrus, Johannes [ZA/ZA]; (ZA) (For US Only)
Inventors: MEYER, Petrus, Johannes; (ZA)
Agent: LE ROUX, Marius; D.M. Kisch Inc. P.O. Box 781218 2146 Sandton (ZA)
Priority Data:
2000/3643 19.07.2000 ZA
Abstract: front page image
(EN)The invention provides for a method for the administration of a nucleic acid substance to the cells of an animal, a plant or a micro-organism the method being characterised in that the nucleic acid substance is formulated with an administration medium which comprises a solution of nitrous oxide gas in a physiologically acceptable carrier solvent for the gas and which administration medium includes at least one fatty acid or ester or other suitable derivative thereof selected from the group consisting of oleic acid, linoleic acid, alpha-linoelic acid, gamma-linolenic acid, arachidonic acid, eicosapentaenoic acid [C20: 5$g(v)3], decosahexaenoic acid [C22: 6$g(v)3], ricinoleic acid and derivatives thereof selected from the group consisting of the C1 to C6 alkyl esters thereof, the glycerol-polyethylene glycol esters thereof and the reaction product of hydrogenated natural oils composed largely of ricinoleic acid based oils, such as castor oil, with ethylene oxide.
(FR)L'invention concerne un procédé d'administration de substance d'acide nucléique aux cellules d'un animal, d'une plante ou d'un micro-orgnanisme. La substance est formulée sur la base d'un milieu d'administration qui comprend une solution de gaz d'oxyde nitreux dans un solvant support physiologiquement acceptable pour le gaz. Le milieu d'administration comprend au moins un acide ou un ester gras ou autre dérivé correspondant approprié, pouvant être acide oléique, acide linoléique, acide alpha-linoléique, acide gamma-linoléique, acide arachidonique, acide éicosapentanoïque [C20: 5$g(v)3], acide décosahexanoïque [C22: 6$g(v)3], acide ricinoléique, et leurs dérivés, pouvant être esters d'alkyle C¿1-6? correspondants, esters de glycérol-polyéthylène glycol correspondants et le produit de la réaction entre des huiles naturelles hydrogénées renfermant essentiellement des huiles à base d'acide ricinoléique (par exemple, huile de ricin), d'une part, et de l'oxyde d'éthylène, d'autre part.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)