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Machine translation
1. (WO2002005792) USE OF MATRIX METALLOPROTEASE INHIBITORS FOR THE TREATMENT OF CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/005792    International Application No.:    PCT/EP2001/008234
Publication Date: 24.01.2002 International Filing Date: 17.07.2001
Chapter 2 Demand Filed:    08.02.2002    
IPC:
A61K 31/00 (2006.01), A61K 31/4439 (2006.01)
Applicants: SIMON, Christian [DE/DE]; (DE).
ZENNER, Hans-Peter [DE/DE]; (DE)
Inventors: SIMON, Christian; (DE).
ZENNER, Hans-Peter; (DE)
Agent: RUFF, WILHELM, BEIER, DAUSTER & PARTNER; Kronenstrasse 30 70174 Stuttgart (DE)
Priority Data:
00114909.5 17.07.2000 EP
Title (EN) USE OF MATRIX METALLOPROTEASE INHIBITORS FOR THE TREATMENT OF CANCER
(FR) UTILISATION D'UN PRINCIPE ACTIF POUR LE TRAITEMENT DU CANCER
Abstract: front page image
(EN)The invention relates to the use of an active agent, particularly an inhibitor, in treating cancer by influencing, preferably inhibiting the expression of matrix-metalloproteases. The targets for this active agent can especially related to downstream regulators of the matrix-metalloprotease 9 (MMP-9) signal transduction pathway. According to the invention, especially inhibitors of p38beta and p38gamma as also of mitogen-activated kinase kinase 6 (MKK6) and mitogen-activated kinase kinase 3 (MKK3) can be applied.
(FR)L'invention concerne l'utilisation d'un principe actif, en particulier d'un inhibiteur, pour le traitement du cancer, ledit principe actif influant sur l'expression de métalloprotéases matricielles. Les cibles de ce principe actif peuvent concerner les régulateurs agissant en aval de la voie de transduction du signal de la métalloprotéase matricielle 9 (MMP-9). Selon l'invention, on peut notamment utiliser des inhibiteurs de p38 bêta et p38 gamma comme kinase kinase 6 activée par mitogène (MKK6) et kinase kinase 3 activée par mitogène (MKK3).
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)