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Machine translation
1. (WO2002005146) METHOD FOR DISIGNING PROTEIN LIBRARIES WITH ALTERED IMMUNOGENICITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/005146    International Application No.:    PCT/US2001/021823
Publication Date: 17.01.2002 International Filing Date: 10.07.2001
Chapter 2 Demand Filed:    15.01.2002    
IPC:
G01N 33/68 (2006.01), C07K 1/00 (2006.01), G01N 33/48 (2006.01), G06F 17/30 (2006.01), G06F 17/50 (2006.01), G06F 19/16 (2011.01), A61K 39/00 (2006.01)
Applicants: XENCOR, INC. [US/US]; 111 W. Lemon Avenue Monrovia, CA 91016 (US)
Inventors: CHIRINO, Arthur, J.; (US).
DAHIYAT, Bassil, I.; (US)
Agent: TRECARTIN, Richard, F.; Flehr Hohbach Test Albritton & Herbert LLP Suite 3400 4 Embarcadero Center San Francisco, CA 94111-4187 (US)
Priority Data:
60/217,661 10.07.2000 US
Title (EN) METHOD FOR DISIGNING PROTEIN LIBRARIES WITH ALTERED IMMUNOGENICITY
(FR) AUTOMATISATION DE CONCEPTION DE PROTEINES POUR LA CONCEPTION DE BIBLIOTHEQUES DE PROTEINES A ANTIGENICITE MODIFIEE
Abstract: front page image
(EN)The present invention relates to the use of a variety of computational methods for modulating the immunogenicity of proteins by identifying and then altering potential amino acid sequences that elicit an immune response in a host organism. In particular, protein will be screened for MHC binding sequences, T cell epitopes and B cell epitopes.
(FR)L'invention concerne l'utilisation d'un éventail de procédés de calcul pour la modulation de l'antigénicité de protéines, à travers l'identification puis la modification de séquences d'acides aminés potentielles qui induisent une réponse immunitaire dans un organisme hôte. En particulier, on effectue un criblage des protéines visant à déterminer les séquences de liaison du CMH, les épitopes de lymphocytes T et les épitopes de lymphocytes B.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)