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Machine translation
1. (WO2002004683) METHOD OF DETECTING AN INCREASED SUSCEPTIBILITY TO BREAST CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/004683    International Application No.:    PCT/US2001/021954
Publication Date: 17.01.2002 International Filing Date: 11.07.2001
Chapter 2 Demand Filed:    31.01.2002    
IPC:
C12Q 1/68 (2006.01)
Applicants: VANDERBILT UNIVERSITY [US/US]; 305 Kirkland Hall, Nashville, TN 37240 (US) (For All Designated States Except US).
PARL, Fritz, F. [US/US]; (US) (For US Only)
Inventors: PARL, Fritz, F.; (US)
Agent: SPRATT, Gwendolyn, D.; Needle & Rosenberg, P.C., Suite 1200, The Candler Building, 127 Peachtree Street, N.E., Atlanta, GA 30303-1811 (US)
Priority Data:
60/217,593 11.07.2000 US
Title (EN) METHOD OF DETECTING AN INCREASED SUSCEPTIBILITY TO BREAST CANCER
(FR) METHODE DE DETECTION D'UNE SENSIBILITE ACCRUE AU CANCER DU SEIN
Abstract: front page image
(EN)The present invention provides methods for identifying a subject having an increased risk of developing an estrogen-related cancer, comprising determining which alleles of the genes encoding CYP1B1, CYP1A1, COMT, and GSTM1 are present in the genome of the subject so as to determine an estrogen metabolizing enzyme genotype for the subject, and correlating the estrogen metabolizing enzyme genotype of the subject to an increased risk of developing an estrogen-related cancer, for example breast cancer. Also provided by the invention are diagnostic kits to determine the presence in a subject of the alleles of the genes encoding CYP1B1, CYP1A1, COMT, and GSTM1.
(FR)La présente invention concerne des méthodes d'identification d'un sujet présentant un risque accru de développer un cancer lié aux oestrogènes, consistant à déterminer quels allèles des gènes codant CYP1B1, CYP1A1, COMT et GSTM1 sont présents dans le génome du sujet, afin de déterminer un génotype d'enzyme métabolisant les oestrogènes pour le sujet, et à corréler le génotype d'enzyme métabolisant les oestrogènes du sujet avec un risque accru de développer un cancer lié aux oestrogènes, par exemple, le cancer du sein. L'invention concerne également des matériels de diagnostic permettant de déterminer la présence chez un sujet des allèles des gènes codant CYP1B1, CYP1A1, COMT et GSTM1.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)