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1. WO2002004646 - EXPRESSION SYSTEM

Publication Number WO/2002/004646
Publication Date 17.01.2002
International Application No. PCT/GB2001/003065
International Filing Date 06.07.2001
Chapter 2 Demand Filed 25.01.2002
IPC
A61K 39/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
C07K 14/32 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195from bacteria
32from Bacillus (G)
CPC
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
C07K 14/32
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195from bacteria
32from Bacillus (G)
C07K 2319/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
C12N 15/70
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
70Vectors or expression systems specially adapted for E. coli
Applicants
  • THE SECRETARY OF STATE FOR DEFENCE [GB]/[GB] (AllExceptUS)
  • WILLIAMSON, Ethel, Diane [GB]/[GB] (UsOnly)
  • MILLER, Julie [GB]/[GB] (UsOnly)
  • WALKER, Nicola, Jane [GB]/[GB] (UsOnly)
  • BAILLIE, Leslie, William, James [GB]/[GB] (UsOnly)
  • HOLDEN, Paula, Thomson [GB]/[GB] (UsOnly)
  • FLICK-SMITH, Helen, Claire [GB]/[GB] (UsOnly)
  • BULLIFENT, Helen, Lisa [GB]/[GB] (UsOnly)
  • TITBALL, Richard, William [GB]/[GB] (UsOnly)
  • TOPPING Andrew William [GB]/[GB] (UsOnly)
Inventors
  • WILLIAMSON, Ethel, Diane
  • MILLER, Julie
  • WALKER, Nicola, Jane
  • BAILLIE, Leslie, William, James
  • HOLDEN, Paula, Thomson
  • FLICK-SMITH, Helen, Claire
  • BULLIFENT, Helen, Lisa
  • TITBALL, Richard, William
  • TOPPING Andrew William
Agents
  • GREAVES, Carol, Pauline
Priority Data
0016702.308.07.2000GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) EXPRESSION SYSTEM
(FR) SYSTEME D'EXPRESSION
Abstract
(EN) An immunogenic reagent which produces an immune response which isprotective against Bacillus anthracis, said reagent compr ising one or more polypeptides which together represent up to three domains of the full length Protective Antigen (PA) of B . anthracis or variants of these, and at least one of said domains comprises domain 1 or domain 4 of PA or a variant ther eof.The polypeptides of the immunogenic reagent as well as full length PA are produced by expression from E. coli. High yields of polypeptide are obtained using this method. Cells, vectors and nucleic acids used in the method are also described and claimed.
(FR) La présente invention concerne un réactif immunogène produisant une réponse immunitaire protectrice contre le bacille du charbon, ce réactif comportant un ou plusieurs polypeptides qui représentent ensemble jusqu'à trois domaines de pleine longueur de l'antigène protecteur (PA) du bacille du charbon ou des variantes de ceux-ci, au moins un desdits domaines comprenant le domaine 1 ou le domaine 4 de l'antigène protecteur ou une variante de celui-ci. Les polypeptides du réactif immunogène ainsi que l'antigène protecteur de pleine longueur sont produits par l'expression de E.coli. Cette méthode permet d'obtenir un rendement élevé de polypeptides. Enfin, cette invention concerne des cellules, des vecteurs et des acides nucléiques utilisés dans cette méthode.
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