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Machine translation
1. (WO2002004638) COMPOUNDS TARGETED TO CELLULAR LOCATIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/004638    International Application No.:    PCT/GB2001/003034
Publication Date: 17.01.2002 International Filing Date: 06.07.2001
Chapter 2 Demand Filed:    09.01.2002    
IPC:
C07K 14/705 (2006.01)
Applicants: ADPROTECH LIMITED [GB/GB]; Chesterford Research Park Little Chesterford Saffron Walden Essex CB10 1XL (GB) (For All Designated States Except US).
ROWLING, Pamela, Jane, Elizabeth [GB/GB]; (GB) (For US Only).
SMITH, Geoffrey, Paul [GB/GB]; (GB) (For US Only).
RIDLEY, Simon, Hugh [GB/GB]; (GB) (For US Only)
Inventors: ROWLING, Pamela, Jane, Elizabeth; (GB).
SMITH, Geoffrey, Paul; (GB).
RIDLEY, Simon, Hugh; (GB)
Agent: DAVIES, Jonathan, Mark; Reddie & Grose 16 Theobalds Road London WC1X 8PL (GB)
Priority Data:
0016811.2 07.07.2000 GB
Title (EN) COMPOUNDS TARGETED TO CELLULAR LOCATIONS
(FR) COMPOSES CIBLES SUR DES POSITIONS CELLULAIRES
Abstract: front page image
(EN)A soluble derivative of a soluble polypeptide, which comprises two or more heterologous membrane binding elements with low membrane affinity covalently associated with the polypeptide, the elements being soluble in aqueous solution, and the elements being capable of interacting, independently and with thermodynamic additivity, with components of cellular or artificial membranes exposed to extracellular fluids, characterised in that the membrane binding elements target lipid raft components of the membrane and bind to the lipid rafts to localize the polypeptide at the lipid rafts.
(FR)L'invention concerne un dérivé soluble d'un polypeptide soluble qui comprend au moins deux éléments de liaison hétérologues membranaires comportant une basse affinité de membrane associés en liaison covalente avec le polypeptide, ces éléments étant solubles en solution aqueuse et pouvant agir en interaction, de manière indépendante et avec une additivité thermodynamique, avec des composants de membranes cellulaires ou artificielles exposées aux liquides extracellulaires, caractérisés par le fait que les éléments de liaison membranaires ciblent les composants de type radeau lipidique et se fixent à ces radeaux lipidiques pour situer le polypeptide sur les radeaux lipidiques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)