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1. (WO2002004458) MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES)
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/004458    International Application No.:    PCT/DK2001/000450
Publication Date: 17.01.2002 International Filing Date: 28.06.2001
Chapter 2 Demand Filed:    17.01.2002    
IPC:
C07D 495/04 (2006.01)
Applicants: NOVO NORDISK A/S [DK/DK]; Novo Allé, DK-2880 Bagsvaerd (DK).
ONTOGEN CORPORATION [US/US]; 6451 El Camino Real, Carlsbad, CA 92009 (US)
Inventors: HANSEN, Thomas, Kruse; (DK).
LAU, Jesper; (DK).
MØLLER, Niels, Peter, Hundahl; (DK).
OLSEN, Ole, Hvilsted; (DK).
AXE, Frank, Urban; (US).
BAKIR, Farid; (US).
GE, Yu; (US).
HOLSWORTH, Daniel, Dale; (US).
JUDGE, Luke, Milburn; (US).
NEWMAN, Michael, James; (US).
UYEDA, Roy, Teruyuki; (US).
SHAPIRA, Barry, Zvi; (US).
ANDERSEN, Henrik, Sune; (DK)
Priority Data:
PA 2000 01066 07.07.2000 DK
Title (EN) MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES)
(FR) MODULATEURS DE PROTEINE TYROSINE PHOSPHATASES (PTPASES)
Abstract: front page image
(EN)The present invention provides novel thienopyridines, novel compositions, methods of their use, and methods of their manufacture, where such compounds of Formula (I) are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) including PTP1B, T cell PTP (TC-PTP), wherein X, R¿1?, R¿2?, R¿3?, and R¿4? are defined more fully in the description. The compounds are useful in the treatment of type 1 diabetes, type 2 diabetes, impaired glucose tolerance, insulin resistance, obesity, and other diseases.
(FR)L'invention concerne de nouvelles thiénopyridines, de nouvelles compositions, leurs procédés d'utilisation et leurs procédés de fabrication. Les composés de la formule 1 sont des inhibiteurs de protéine tyrosine phosphatases (PTPases) pharmacologiquement utiles comprenant PTP1B, PTP de cellule T, X, R1, R2, R3 et R4 étant définis plus en détail dans le descriptif. Les composés sont utiles dans le traitement des diabètes des types I et II, de l'intolérance au glucose, de la résistance insulinique, de l'obésité et d'autres maladies.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)