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1. (WO2002004438) BIFUNCTIONAL AGENTS POSSESSING ANTIOXIDANT AND ANTIARRHYTHMIC ACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/004438    International Application No.:    PCT/GR2001/000030
Publication Date: 17.01.2002 International Filing Date: 04.07.2001
Chapter 2 Demand Filed:    23.01.2002    
IPC:
C07D 311/66 (2006.01), C07D 311/72 (2006.01)
Applicants: UNI-PHARMA KLEON TSETIS PHARMACEUTICAL LABORATORIES S.A. [GR/GR]; 14 km National Road 1 GR-14565 Kifissia (GR) (For All Designated States Except US).
KOUFAKI, Maria [GR/GR]; (GR) (For US Only).
CALOGEROPOUL0U, Theodora [GR/GR]; (GR) (For US Only).
MAKRIYANNIS, Alexandros [US/US]; (US) (For US Only)
Inventors: KOUFAKI, Maria; (GR).
CALOGEROPOUL0U, Theodora; (GR).
MAKRIYANNIS, Alexandros; (US)
Agent: GRISPOU, Maria; 22A Chalkidos St. GR-11143 Athens (GR)
Priority Data:
20000100231 12.07.2000 GR
Title (EN) BIFUNCTIONAL AGENTS POSSESSING ANTIOXIDANT AND ANTIARRHYTHMIC ACTIVITY
(FR) AGENTS BIFONCTIONNELS A ACTIVITE ANTIOXYDANTE ET ANTIARYTHMIQUE
Abstract: front page image
(EN)The present invention relates to novel bifunctional agents possessing antioxidant and antiarrhytmic activity, methods for the synthesis of the same and their applications in treating ischemia-reperfusion injury, as well as a variety of disorders related to free radicals and/or arrhythmias. These bifunctional drugs should preferentially segregate in the membrane and produce their antiarrhytmic effects while, at the same time, help in protecting the membrane lipids by scavenging free radicals. The present invention comprises compounds represented by Formula (I), wherein R¿1?, R¿2?, R¿3?, R¿4?, R¿5? are further defined.
(FR)La présente invention concerne de nouveaux agents bifonctionnels à activité antioxydante et antiarythmique, des méthodes de synthèse de ceux-ci et leurs applications dans le traitement des lésions d'ischémie-reperfusion, ainsi que de divers troubles associés aux radicaux libres et/ou aux arythmies. Ces médicaments bifonctionnels doivent, de préférence, être séparés dans la membrane et produire leurs effets antiarythmiques tout en aidant à protéger les lipides de la membrane en piégeant les radicaux libres. La présente invention comprend des composés représentés par la formule (I), dans laquelle R1, R2, R3, R4, R5 sont tels que définis dans les revendications.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)