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1. WO2002004406 - 9-SUBSTITUTED MINOCYCLINE COMPOUNDS

Publication Number WO/2002/004406
Publication Date 17.01.2002
International Application No. PCT/US2001/020721
International Filing Date 29.06.2001
Chapter 2 Demand Filed 05.02.2002
IPC
C07C 237/26 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
237Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
24having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
26of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
C07C 255/59 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
255Carboxylic acid nitriles
49having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
58containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
59the carbon skeleton being further substituted by singly-bound oxygen atoms
C07C 271/22 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
271Derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
06Esters of carbamic acids
08having oxygen atoms of carbamate groups bound to acyclic carbon atoms
10with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
22to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
C07C 271/28 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
271Derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
06Esters of carbamic acids
08having oxygen atoms of carbamate groups bound to acyclic carbon atoms
26with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
28to a carbon atom of a non-condensed six-membered aromatic ring
C07C 271/30 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
271Derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
06Esters of carbamic acids
08having oxygen atoms of carbamate groups bound to acyclic carbon atoms
26with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
30to a carbon atom of a six-membered aromatic ring being part of a condensed ring system
C07C 271/58 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
271Derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
06Esters of carbamic acids
40having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
58with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
CPC
A61K 31/65
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
65Tetracyclines
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61P 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07C 237/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
237Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
Applicants
  • TRUSTEES OF TUFTS COLLEGE [US]/[US]
  • PARATEK PHARACEUTICALS, INC. [US]/[US]
Inventors
  • NELSON, Mark, L.
  • FRECHETTE, Roger
  • VISKI, Peter
  • ISMAIL, Mohamed
  • BOWSER, Todd
  • DUMORNAY, Jimmy
  • RENNIE, Glen
  • LIU, Gui
  • KOZA, Darrell
  • SHEAHAN, Paul
  • STAPLETON, Karen
  • HAWKINS, Paul
  • BHATIA, Beena
  • VERMA, Atul
  • MCINTYRE, Laura
  • WARCHOL, Tad
Agents
  • HANLEY, Elizabeth, A.
Priority Data
60/216,65907.07.2000US
60/275,62113.03.2001US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) 9-SUBSTITUTED MINOCYCLINE COMPOUNDS
(FR) COMPOSES DE MONOCYCLINE 9-SUBSTITUES
Abstract
(EN) The present invention pertains, at least in part, to novel 9- substituted minocycline compounds. These minocyline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
(FR) La présente invention concerne, au moins en partie, des composés de minocycline 9- substitués. Ces composés de minocycline peuvent être utilisés dans le traitement de nombreux états réagissant à des composés de la tétracycline, tels que des infections bactériennes et des tumeurs ainsi que pour d'autres applications connues des composés de la minocycline et de la tétracycline en général, par exemple pour le blocage l'efflux de la tétracycline et la modulation de l'expression génique.
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