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1. (WO2002004404) 7,8 AND 9-SUBSTITUTED TETRACYCLINE COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/004404    International Application No.:    PCT/US2001/020558
Publication Date: 17.01.2002 International Filing Date: 29.06.2001
Chapter 2 Demand Filed:    01.02.2002    
IPC:
C07C 237/26 (2006.01)
Applicants: TRUSTEES OF TUFTS COLLEGE [US/US]; * (US)
Inventors: NELSON, Mark, L.; (US).
KOZA, Darrell; (US)
Agent: HANLEY, Elizabeth, A.; Lahive & Cockfield, LLP 28 State Street Boston, MA 02109 (US)
Priority Data:
60/216,656 07.07.2000 US
PCT/US00/21366 04.08.2000 US
Title (EN) 7,8 AND 9-SUBSTITUTED TETRACYCLINE COMPOUNDS
(FR) COMPOSES DE TETRACYCLINE SUBSTITUES EN 7, 8 ET 9
Abstract: front page image
(EN)7,8 and 9-substituted tetracyline compounds of the formula (I) wherein: R?4¿ and R?4'¿ are each methyl; R?5¿ is hydrogen or hydroxyl; R?6¿ and R?6'¿ are each independently hydrogen, methyl, or hydroxyl; R?7¿ is hydrogen, lower alkenyl, lower alkynyl, phenyl, halophenyl, acyl, phenylalkynyl, heteroaryl, or dimethylamino; and R?8¿ is hydrogen, phenyl, nitrophenyl, halo, or lower alkynyl; and R?9¿ is hydrogen, amino, acetamide, or lower alkynyl; and provided that at least one of R?7¿, R?8¿, or R?9¿ is not hydrogen, methods of treating tretracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are described.
(FR)L'invention concerne des composés de tétracycline substitués en 7, 8 et 9, des méthodes de traitement de troubles sensibles à la tétracycline, et des compositions pharmaceutiques contenant lesdits composés de tétracycline substitués en 7,8 et 9.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)