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1. (WO2002003998) MACROLIDE FORMULATIONS FOR INHALATION AND METHODS OF TREATMENT OF ENDOBRONCHIAL INFECTIONS

Pub. No.:    WO/2002/003998    International Application No.:    PCT/US2001/041328
Publication Date: Jan 17, 2002 International Filing Date: Jul 10, 2001
IPC: A61K 9/00
A61K 9/72
A61K 31/7048
A61M 11/00
A61M 13/00
A61P 11/00
A61P 31/04
Applicants: CHIRON CORPORATION
BAKER, William, R.
CHALLONER, Peter, B.
SHAWAR, Ribhi, M.
HUH, KAY, K.
RYCMAN, David, M.
Inventors: BAKER, William, R.
CHALLONER, Peter, B.
SHAWAR, Ribhi, M.
HUH, KAY, K.
RYCMAN, David, M.
Title: MACROLIDE FORMULATIONS FOR INHALATION AND METHODS OF TREATMENT OF ENDOBRONCHIAL INFECTIONS
Abstract:
Macrolide formulations, such as an erythromycylamine formulation, for delivery by aerosolization are described. The concentrated erythromycylamine formulations contain an amount of erythromycylamine effective to treat infections caused by susceptible bacteria. Unit dose devices having a container containing a formulation of the macrolide antibiotic in a physiologically acceptable carrier are also described. Methods for treatment of pulmonary infections by a formulation (liquid solution, suspension, or dry powder) delivered as an aerosol having mass median aerodynamic diameter predominantly between 1 to 5 νm are also described.