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Machine translation
1. (WO2002003994) N SULFONYL AMINOACID DERIVATIVES AS INHIBITORS OF METALLOPROTEINASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/003994    International Application No.:    PCT/US2000/021024
Publication Date: 17.01.2002 International Filing Date: 01.08.2000
IPC:
A61K 31/5375 (2006.01), A61K 31/63 (2006.01)
Applicants: G.D. SEARLE & CO. [US/US]; Corporate Patent Department P.O. Box 5110 Chicago, IL 60680-5110 (US) (For All Designated States Except US).
STALLINGS, William, C. [US/US]; (US) (For US Only).
SHIEH, Huey, S. [US/US]; (US) (For US Only).
HOWARD, Susan, C. [US/US]; (US) (For US Only).
DE CRECENZO, Gary, A. [US/US]; (US) (For US Only).
MC DONALD, Joseph, J. [US/US]; (US) (For US Only)
Inventors: STALLINGS, William, C.; (US).
SHIEH, Huey, S.; (US).
HOWARD, Susan, C.; (US).
DE CRECENZO, Gary, A.; (US).
MC DONALD, Joseph, J.; (US)
Agent: WARNER, James, M.; G.D. Searle & Co. Corporate Patent Department P.O. Box 5110 Chicago, IL 60680-5110 (US)
Priority Data:
PCT/US00/16323 12.07.2000 US
Title (EN) N SULFONYL AMINOACID DERIVATIVES AS INHIBITORS OF METALLOPROTEINASE
(FR) DERIVES D'ACIDES AMINES N SULFONYLE INHIBITEURS DES METALLOPROTEINASES
Abstract: front page image
(EN)The present invention provides a matrix metalloproteinase inhibiting compound having the structure (I), or a salt, an enantiomer, a diastereomer, a racemate, or a tautomer thereof. In other embodiments, the present invention provides a method of changing the conformation of a matrix metalloproteinase, a method of inhibiting a matrix metalloproteinase, and a method of treating osteoarthritis.
(FR)La présente invention concerne un composé inhibiteur des métalloprotéinases matricielles représenté par la structure (I), ou un sel, un énantiomère, un diastéréomère, un racémate, ou un tautomère de celui-ci. Dans d'autres modes de réalisation, la présente invention concerne une méthode visant à modifier la conformation d'une métalloprotéinase matricielle, une méthode d'inhibition des métalloprotéinases matricielles, et une méthode de traitement de l'ostéoarthrite.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CR, CU, CZ, DE, DK, DM, DZ, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)