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1. (WO2002003990) USE OF SUBSTITUTED INSOLE COMPOUNDS FOR TREATING EXCESSIVE INTRAOCULAR PRESSURE

Pub. No.:    WO/2002/003990    International Application No.:    PCT/US2001/021082
Publication Date: Jan 17, 2002 International Filing Date: Jun 29, 2001
IPC: A61K 31/4045
A61K 31/454
A61K 31/55
Applicants: WYETH
Inventors: JENKINS, Simon, Nicholas
Title: USE OF SUBSTITUTED INSOLE COMPOUNDS FOR TREATING EXCESSIVE INTRAOCULAR PRESSURE
Abstract:
This invention comprises methods of treatment, prevention, inhibition or alleviation of the problems associated with excessive intraocular pressure comprising administration of a compound of the formulae (I) or (II): wherein Z is a moiety selected from the group of formulae (III) or (IV): wherein R1 is selected from H, OH or the C1-C12 esters or C1-C12 alkyl ethers thereof, or halogens; or C1-C4 halogenated ethers including trifluoromethyl ether and trichloromethyl ether; R2, R3, R4, R5, and R6 are H, OH or C1-C12 esters or C1-C12 alkyl ethers thereof, halogens, or C1-C4 halogenated ethers, cyano, C1-C6 alkyl, or trifluoromethyl, with the proviso that, when R1 is H, R2 is not OH; Y is the moiety formula (V): R7 and R8 are alkyl or concatenated together to form an optionally substituted nitrogen-containing ring; or a pharmaceutically acceptable salt thereof.