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1. WO2002003961 - MICROSPHERES AND ADJUVANTS FOR DNA VACCINE DELIVERY

Publication Number WO/2002/003961
Publication Date 17.01.2002
International Application No. PCT/US2001/021780
International Filing Date 09.07.2001
Chapter 2 Demand Filed 16.01.2002
IPC
A61K 9/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 9/16 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
16Agglomerates; Granulates; Microbeadlets
CPC
A61K 9/1647
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
16Agglomerates; Granulates; Microbeadlets ; ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
1605Excipients; Inactive ingredients
1629Organic macromolecular compounds
1641obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
1647Polyesters, e.g. poly(lactide-co-glycolide)
A61P 31/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
06for tuberculosis
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • CORIXA CORPORATION [US]/[US]
Inventors
  • JOHNSON, Mark, E.
  • MOSSMAN, Sally
  • CECIL, Tricia
  • EVANS, Lawrence
Agents
  • CANADY, Karen, S.
Priority Data
60/216,60407.07.2000US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) MICROSPHERES AND ADJUVANTS FOR DNA VACCINE DELIVERY
(FR) MICROSPHERES ET ADJUVANTS UTILISES POUR L'ADMINISTRATION DE VACCINS A BASE D'ADN
Abstract
(EN) A nucleic acid delivery system that offers, in one system, a combination of high encapsulation efficiency, rapid release kinetics and preservation of DNA in supercoiled form is provided. The nucleic delivery system comprises nucleic acid molecules, such as deoxyribonucleic acid (DNA), encapsulated in biodegradable microspheres, and is particularly suited for delivery DNA vaccines. The ivnention futher provides a method for encapsulating nucleic acid molecules in microspheres. The invention additionally provides a composition comprising nucleic acid molecules encapsulated in microspheres produced by a method of the invention, and a method for delivering a nucleic acid molecule to a subject. The invention futher provides an adjuvant for modulating the immunostimulatory efficacy of microspheres encapsulating nucleic acid molecules comprising an aminoalkyl glucosaminide 4-phosphate (AGP). The invention also provides a method for modulating the immunostimulatory efficacy of microspheres encapsulating nucleic acid molecules.
(FR) La présente invention concerne un système d'administration d'acides nucléique qui offre, dans un seul système, une combinaison d'efficacité d'encapsulation élevée, de cinétique de libération rapide et de préservation d'ADN superenroulé. Ce système de distribution nucléique comprend des molécules d'acides nucléiques, notamment l'acide désoxyribonucléique (ADN), encapsulées dans des microsphères biodégradables, et convenant particulièrement à l'administration de vaccins à base d'ADN. Par ailleurs, cette invention concerne une méthode d'encapsulation de molécules d'acides nucléiques dans des microsphères. De plus, cette invention concerne une composition renfermant des molécules d'acides nucléiques encapsulées dans des microsphères obtenues par une méthode de l'invention, et une méthode d'administration de molécules d'acides nucléiques à un sujet. L'invention concerne également un adjuvant utilisé pour moduler l'efficacité immunostimulatrice des molécules d'acides nucléiques encapsulées dans des microsphères renfermant un aminoalkyle glucosaminide 4-phosphate (AGP). Enfin, l'invention concerne une méthode de modulation de l'efficacité immunostimulatrice des molécules d'acides nucléiques encapsulées dans des microsphères.
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