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1. (WO2002003071) MODULATORS OF TRK PROTEIN ACTIVITY, COMPOSITIONS AND USES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/003071    International Application No.:    PCT/US2001/021472
Publication Date: 10.01.2002 International Filing Date: 05.07.2001
Chapter 2 Demand Filed:    25.01.2002    
IPC:
A61K 38/18 (2006.01), G01N 33/68 (2006.01)
Applicants: PANGENE CORPORATION [US/US]; 5500 Stewart Avenue Fremont, CA 94538 (US) (For All Designated States Except US).
BATES, Alan, Thomas [US/US]; (US) (For US Only)
Inventors: BATES, Alan, Thomas; (US)
Agent: SILVA, Robin, M.; Flehr Hohbach Test Albritton & Herbert LLP Suite 3400 4 Embarcadero Center San Francisco, CA 94111-4187 (US)
Priority Data:
60/215,778 05.07.2000 US
Title (EN) MODULATORS OF TRK PROTEIN ACTIVITY, COMPOSITIONS AND USES
(FR) MODULATEURS DE L'ACTIVITE DE LA PROTEINE TRK, ET COMPOSITIONS ET METHODES D'UTILISATION
Abstract: front page image
(EN)The present invention concerns receptor tyrosine kinases and ligands therefore that modulate cell growth, differentiation, and survival. Particularly, the present invention concerns the TrK family of receptor tyrosine kinases known to mediate the activities of neurotrophins. TrK proteins are also known proto-oncogenes. Small molecule compositions for the modulation of TrK protein binding and activity are provided. Also provided are methods for screening for small molecules capable of binding to TrK protein binding one or more neurotrophin binding determinants in TrK proteins.
(FR)L'invention porte sur des tyrosine kinases réceptrices et les ligands à cet effet modulant la croissance, la différentiation et la survie des cellules. Elle porte particulièrement sur la famille Trk des tyrosine kinases réceptrices connues pour médier les activités des neurotrophines, les protéines Trk étant également des proto-oncogènes connus; sur des compositions de petites molécules modulant la fixation et l'activité de la protéine Trk; et sur des procédés de criblage de petites molécules pouvant se fixer à la protéine Trk en se fixant à un ou plusieurs de ses déterminants de fixation à la neurotrophine.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)