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1. (WO2002002773) DUAL SPECIFICITY ANTIBODIES AND METHODS OF MAKING AND USING
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2002/002773    International Application No.:    PCT/US2001/020755
Publication Date: 10.01.2002 International Filing Date: 28.06.2001
Chapter 2 Demand Filed:    28.01.2002    
IPC:
A61K 47/48 (2006.01), C07K 16/24 (2006.01), G01N 33/68 (2006.01)
Applicants: ABBOTT LABORATORIES [US/US]; 100 Abbott Park Road, Abbott Park, IL 60064 (US) (For All Designated States Except US).
COLLINSON, Albert [US/US]; (US) (For US Only).
GHAYUR, Tariq [PK/US]; (US) (For US Only).
AVGERINOS, George [US/US]; (US) (For US Only).
DIXON, Richard [US/US]; (US) (For US Only).
KAYMAKCALAN, Zehra [US/US]; (US) (For US Only)
Inventors: COLLINSON, Albert; (US).
GHAYUR, Tariq; (US).
AVGERINOS, George; (US).
DIXON, Richard; (US).
KAYMAKCALAN, Zehra; (US)
Agent: DECONTI, Giulio, A.; Lahive & Cockfield, LLP, 28 State Street, Boston, MA 02109-1784 (US)
Priority Data:
60/215,379 29.06.2000 US
Title (EN) DUAL SPECIFICITY ANTIBODIES AND METHODS OF MAKING AND USING
(FR) ANTICORPS A DOUBLE SPECIFICITE, PROCEDES DE FABRICATION ET D"UTILISATION
Abstract: front page image
(EN)Antibodies having dual specificity for two different but structurally related antigens are provided. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have dual specificity for IL-1$g(a) and IL-1$g(b) and neutralize IL-1$g(a) and IL-1$g(b) activity in vitroand in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting two different but structurally related antigens (e.g., IL-1$g(a) and IL-1$g(b)) and for inhibiting the activity of the antigens, (e.g., in a human subject suffering from a disorder in which IL-1$g(a) and/or IL-1$g(b) activity is detrimental.
(FR)La présente invention concerne des anticorps à double spécificité pour deux antigènes distincts mais structurellement connexes. Ces anticorps peuvent être notamment des anticorps entièrement humains, des anticorps de recombinaison, ou des anticorps monoclonaux. Les anticorps préférés, qui présentent une spécificité double pour l"IL-1$g(a) et l"IL-1$g(b), neutralisent les activités IL-1$g(a) et IL-1$g(b) aussi bien in vitro qu"in vivo. Un anticorps selon l"invention peut être un anticorps pris sur toute sa longueur, ou uniquement la partie de cet anticorps se liant à un antigène. L"invention concerne également des procédés de fabrication et des procédés d"utilisation des anticorps de l"invention. Les anticorps ou les parties d"anticorps de l"invention conviennent pour la détection de deux antigènes distincts mais structurellement connexes tels que l"IL-1$g(a) et l"IL-1$g(b), et pour l"inhibition de l"activité des antigènes notamment chez un sujet humain soufrant de troubles imputables à l"activité IL-1$g(a) et/ou IL-1$g(b).
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)